I read about a study being done by a doctor at a hospital in western MA on the treatment of depression using either progeterone or estrogen, depending on the type of depression (anxiety or lethargy). The progesterone was used for anxiety forms(I cant remember how it was administered - rubbing cream on the belly maybe? - and I cant remember if wild yam cream was looked at as well). I found this very interesting as I have chronic low estrogen, needed clomid to concieve, and then felt the best Ive ever felt in my life being pregnant. I have the lethargy type of depression so it would make sense that the high levels of estrogen would boost my mood. Howvever, low estrogen and nursing go hand in hand - if you increase estrogen your milk dries up, soooo I have not yet pursued this treatment as I have either been trying to get pregnant or been pregnant or been nursing for the past 4+years, during which time I read the article. But to make a long story short, yes, estrogen could certainly be a viable treatment if you are not nursing.