I would say start small and work your way up when your on a roll.
Start w your closet. Get rid of anything that has not been worn in over a year (pregncy not icl). Throw out dated looking shoes, purses etc. Start a big hefty bag for good will.
Wait about 2-3 days
Then- tackle the file cabinet next to the computer. Shred tax records before 1998. Shred all the other "stuff" and organize the cabinet better. Throw out your high school certificates etc. (no one cares you lettered in track your JR year or your honor roll sheet anymore kwim?). After doing the file cabinet, add paper to the printer dust behind the monitor etc. Clear off the desk. You'll feel great btw.
Wait another few days-
Hit the kitchen cabinets.
By know you should be ruthless in your quest. DH will either be really ticked or right there along w you since you he was either glad your threw the stuff out or mad since you threw out his selection of photo negatives from high school kwim?
Go thru all the glasses. Throw out the plastic soveneer cups from the concerts and zoo things this past summer. Re arrange the glasses. Toss a few mugs that are scratched or from vacation destinations you are not sure when you went to. Get rid of the extra glasses that do not match from when you and DH got together. Who cares- hes already mad anyway
If your feeling confident- hit the spices. I think you know the drill.