post #161 of 161
I came across recent vitamin D research on cancer prevention and treatment again and wanted to mention in this thread b/c I though you would find it interesting:

Quote:
Efficacy and mechanism of action of 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha[OH]D5) in breast cancer prevention and therapy.

It is now well established that the active metabolite of vitamin D3, 1alpha,25(OH)2D3, regulates cell growth and differentiation in various in vitro cancer models. However, its clinical use is precluded due to its hypercalcemic activity in vivo. Hence, several less calcemic vitamin D analogs have been synthesized and evaluated for their chemopreventive and therapeutic efficacy in experimental carcinogenesis models.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

Chemoprevention of mammary carcinogenesis by 1alpha-hydroxyvitamin D5, a synthetic analog of Vitamin D.
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=12628523

Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1alpha-hydroxyvitamin D5.
http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=9017001
Several companies are now developing vitamin D analogs (only one component of entire vit. D structure, ie. D5) to treat cancer. However, we know from WAPF that these forms are not as effective as the whole vitamin in say, cod liver oil which contains somewhere around 20 components I think. And the single D components by themselves are toxic. As this study mentioned: D3 to excess in human studies (D3 is the form that fortifies most commercial milk) at cancer treatment dosages creates hypercalcemia. So now D5 is being focused upon.

But if vitamin A and magnesium were also in the picture, together with natural, whole vitamin D, these toxic side effects would not happen.

I haven't come across a dosage for humans yet as far as what is effective prevention or treatment. WAPF recommends 5,000IU/D per day based on amounts in native diets. This is D fom whole food sources including CLO, and tempered by 10x that amount in whole food sourced vitamin A. (I know most everyone on this thread knows that but you know how I'm the resident fat soluble vitamin cheerleader. ).