Yes, yes you can and you will probably love it!
This will be my first post on MDC (although I've been a reader for a while) because I can't resist sharing that yes, we have done this and it felt amazing.

Twice I've moved across country, East to West and then West to Midwest. Both times I pared down to only the things that would fit inside my Jeep once my queen size futon was placed in there.
The first move I wasn't long out of college so I hadn't collected too much junk. The second time the two of us had set up "house" and were dedicated to just ditching everything that wouldn't fit into our 2 cars before the move. We made $1,000 at our yard sale, selling all of our thrift store furniture and second hand housewares. No joke. We unloaded a lot of stuff. As things started to sell, we just kept adding more, bringing it out and saying, let's just see if this will go. In the end, it felt so good not to have to spend emotional energy worrying about moving, storing, and protecting stuff that we didn't really care about.
After arriving, we switched to public transportation and ditched our second car. We managed to stay minimalist until DH got a different job so he works out of our home (enter tons of office paper and work materials) and we decided to have a wedding. Ugh, major source of clutter.

:
We're in our first home now and with a new baby we're fighting our way back out of clutter again. For us, the key thing to letting go is that lots of our stuff comes from thrift stores so its not difficult to let go of because we didn't spend much to acquire it in the first place. In fact, our current clutter problems stems almost entirely from owning brand new items or receiving too many gifts that were new and expensive so its difficult for us to part with them. (I know, I am so ungrateful).

But the truth is, I don't want stuff in my life taking up space and time. Once we can find a way out of the guilt of giving away gifts, we'll be paring down again.