This is all very interesting and I'm enjoying the food for thought...just thought I'd share my experience...
I am isoimmunized for anti-D. I was given Win-RHO (Canadian version of RhoGAM) during my first pg at 13 weeks (bleeding), 30 weeks, and at delivery. I was testing negative for antibodies up until delivery. We lost my daughter when I was 40 weeks pg and the follow up pathology on the placenta indicated that there was a "feto-maternal hemorrhage" (even though I had no signs of bleed) at the end of the pg (that and massive inflammation of the placenta--so some type of reaction was going on--no infections were found in my b/w results). With my second pg, the initial b/w indicated that I had become sensitized. I find your info very thought-provoking MT...maybe more was going on that we realized with the WinRHO. Like many people's experiences with vaxes, we were told that with me being Rh neg, it was just something we HAD to do...and also that it was almost 100% effective (so imagine my surprise when I found out I had been sensitized anyway after all those shots).
My second pg went fairly well...my DH is homozygous positive for D, so any additional pgs will be affected as well. My titers stayed fairly low (highest was 1:8), my DD did not become overly anemic and only needed the lights for a week, but no transfusions, after she was born.
We are considering trying for a third child and are meeting with the perinatalogist to get an idea of what to expect this time around.
|As an rh- woman myself who is only able to have rh+ babies dur to my dh being heterozygous positive
If your DH was heterzygous, would you have a chance that your baby could be neg for D? That was why we had my DH tested because of that possibility he could be +/- and we could end up with an unaffected baby...My DH turned out to be homozygous for D, so we're stuck with every pg being affected. Well, that's how it was explained to us anyway.