Originally Posted by EBG
I think no enzyme will help with the caffeine. I know weak coffee is legal but I feel so much better without it.
As a habitual coffee drinker, I found this paper to be interesting.
From Acta Medica 2004: 47(4): 273-276
"The impairment of gastroduodenal mucosal barrier by coffee"
L'ubica Cibickova, Norbert Cibicek, Petr Zdansky, Pavel Kohout
Summary: Background: Even though coffee is not considered to be responsible for development of peptic ulcer, it may, however, prolong its healing by increasing acidity of gastric content. In our former work we observed a profound increase in sucrose permeability (above normal values) in healthy volunteers regularly drinking coffee for years. In literature, many
factors affecting sucrose permeability have been described so far. None of them, however, studied the effect of coffee.
Subjects, materials and methods: l0 young asymptomatic habitual coffee drinkers were included in the study. The probands underwent SaLM test twice - first time without coffee restriction and second time after 48-hour coffee abstinence. The ingested SaLM solution comprised sucrose (25.0 g), lactulose ( 10.0 e), mannitol (2.0 g), xylose (2.0 g) and water (up to 100 ml). Urine was collected for five hours and the samples were analysed using gas chromatography. Results were compared with those of 8 young healthy volunteers not drinking coffee. Permeability for sucrose was significantly higher in the group of habitual coffee drinkers in comparison with noncoffee drinkers (p<0.01). After 48-hour coffee abstinence sucrose excretion decreased significantly (p<0.05) to a level not differing from that of non-coffee drinkers (p=0.54).
Conclusions: Our results indicate that coffee may damage gastroduodenal mucosa in habitual coffee drinkers. In a time period of 48 hours the gastroduodenal mucosa is capable of a significant regeneration.
The group's recommendation is that patients undergoing an intestinal permeability test should avoid coffee for more than two days before taking the test. Those recommendations have not yet been included into Great Smokies' permeability test - they only require an 8 hour fast (including no water) prior to taking the test.