MMR given in infancy (NIH study now recruiting)

[LongIsland]

http://www.clinicaltrials.gov/ct/sho...240916?order=3

This is an open-label immunogenicity and safety study of live attenuated Measles Vaccine (Attenuvax) and Measles-Mumps-Rubella (MMR-II) vaccine administered to healthy children at 6, 9, or 12 months of age. Both vaccines are licensed in the U.S. for use in infants.

The purpose of the study is to evaluate the acquisition of measles specific CD4 T cell immunity elicited by vaccination in relation to age at vaccination and to evaluate the safety of an early two dose measles vaccine regimen in infancy.

210 healthy children will be randomized to one of three vaccine cohorts.
Cohort 1 will receive Attenuvax at 6 months of age followed by MMR-II at 12 months. Cohort 2 will receive Attenuvax at 9 months of age followed by MMR-II at 12 months. Cohort 3 will receive MMR-II at 12 months.

All children will be followed through 18 months of age for development of measles-specific immune responses.

.

[alegna]

sigh....

[cravenab00]

no end in sight.

how long before all vaccines are given at birth?

"its a boy!" "no you cant hold him until we vaccinate him, you might contaminate him" :

[taterbug1999]

What on earth do you think they're doing to the vax now to try to make it effective at such an early age? Cause historically under 12 mos it is ineffective. Where are the voices in the medical community to cry out about this lunacy?!?!?!

[krissi]

How nice that they'll only be followed until 18 months of age, before the parents will see any definitive signs of developmental delays resulting from this experiment.

[LongIsland]

Originally Posted by taterbug1999

Cause historically under 12 mos it is ineffective.

Only monovaelent measles vaccine has been studied in infants less than 12 months and they actually give the measles vax to infants beginning at 9 month in Africa.

The MMR II product insert says that infants should only receive the MMR in measles outbreak situations, then get vaxed again at the recommended intervals because mumps and rubella efficacy are unknown.

[chersolly]

They're only following them from 1 year - 6 months? WTH!

[EVC]

This is so very sad. Those poor babies

[LongIsland]

Why Children Die of Measles thread: http://www.mothering.com/discussions...d.php?t=557178

[HeatherHeather]

Yeah, and 210 subjects is enough to show safety. :

[Blue Lotus]

Are they insane??? :

[bri52582]

wouldnt these trials have to stop if people stopped volunteering?? or are these the type that are dont without being consented to participate?? these are just administered along with the already approved shots at the designated WBV and then noted and follow ups..all without mentioned to the mom??

**so sad**poor kids**

[lizzie]

Originally Posted by cravenab00

no end in sight.

how long before all vaccines are given at birth?

"its a boy!" "no you cant hold him until we vaccinate him, you might contaminate him" :

I'm sure that's someone's master plan.

[mamakay]

I wonder if it might have something to do with this:
(another trial going on in Africa).
http://www.clinicaltrials.gov/ct/gui...168545?order=5

There have, though, been some periods without DTP in Bissau due to global shortage of vaccines, and we have compared the case fatality at the hospital for children who received only OPV and children who received both the prescribed OPV and DTP. Children having received OPV had 3-fold lower mortality than children having received both vaccines. Data from an OPV vaccination campaign that took place in Guinea-Bissau also suggested a non-specific beneficial effect for the recipients. Further, studies from Chile and the Soviet Union have suggested that OPV had a beneficial effect on mortality and morbidity.

Specifically, among children who have received the 3 recommended doses of DTP, we will be able to compare the cytokine and antibody profiles of children who receive an early dose of measles vaccine at 4½ months of age with children who receive no additional vaccine at this age.

They're trying to see if an early measles vax will "fix" whatever in the DTP is killing them...

[EENS]

I have a question - why in the would a parent volunteer their child to be a guinea pig? I can't imagine ever, and I mean EVER, signing my precious children up to participate in this or any other study.

[LongIsland]

Originally Posted by EENS

I have a question - why in the would a parent volunteer their child to be a guinea pig?

Millions of parents do it every day . . . right in the pediatrician's office.

[Momtezuma Tuatara]

I like this wee bit from the long list of contraindicated "babies" bit

Current febrile respiratory illness or other active febrile infection
Family history of congenital/hereditary immunodeficiency, unless immune competence of subject has been determined.

Will those kids be put on any contraindicated list if this trial gives them the info they "want"?

Course not.

[Momtezuma Tuatara]

Originally Posted by LongIsland

Millions of parents do it every day . . . right in the pediatrician's office.

correct. And they have no idea that they have.

[HeatherHeather]

Originally Posted by Momtezuma Tuatara

correct. And they have no idea that they have.

It's all in how they "frame" it. When the MD says, "This is a great opportunity. You can have your child protected from the horrible, deadly disease at 6 months when most people have to wait until 18 mos. They're going to recommmend it soon for all children at 6 mos., so of course it's safe, They've been vaxing babies at younger ages in other countries for decades, blah, blah, blah."