Anyone want to weigh in here?
post #181 of 390
1/11/07 at 11:19am
Does anyone know if there are any studies on whether eating low levels of known allergens which don't cause obvious symptoms actually causes an immune response or not?
this is the basis of desensitization using oral tolerance and elimination diets.
one eliminates the food for some period of time. then the offending food is reintroduced - a little experimentation takes place to find the oral tolerance dosage but then the desensitization process occurs over a long period of time using that dosage. presumably, the dosage is low enough to NOT provoke an immune response.
food allergies are dependent largely on both the integrity of the gut mucosa (i.e., the lining of the gut) and the quality of the microbial flora. food allergies arise because of damage to the gut mucosa (and disruption to "gut homeostasis") and failure to achieve oral tolerance. diseases like IBS/IBD arise because of failure to achive tolerance to the microbial flora (but still a type of disruption to "gut homeostasis").
here's a real gem...
BRANDTZAEG Current Understanding of Gastrointestinal Immunoregulation and Its Relation to Food Allergy Annals of the NY Acad Sci. Volume 964, 2002, pp 13-45
Tolerance to food antigens induced via the gut ("oral tolerance") appears to be a rather robust adaptive immune mechanism. However, the neonatal period is particularly critical in terms of mucosal defense, with regard to infections and priming for allergic disease. This is so because the intestinal barrier function provided by secretory antibodies, as well as the immunoregulatory network, is poorly developed for a variable period after birth. Notably, the postnatal development of mucosal immune homeostasis depends on the establishment of a normal commensal microbial flora and also on adequate timing and dose of dietary antigens when first introduced. In this context, breastfeeding apears to exert both shielding and positive regulatory effects. Altogether, the intestinal immune system normally seems rather fit for tolerance induction against innocuous antigens because most children with food allergy "outgrow" their problems, whereas airway allergy tends to persist.
-- inducing oral tolerance requires an intact gut lining
-- a recent Finnish study should that atopic infants had more clostridia and tended to have fewer bidifidobacteria in their stool compared to nonatopic controls
-- it appears that mixed feeding (rather than abrupt weaning) appears to promote tolerance to food proteins and avoidance of potentially harmful of cross-reactive auto-antibodies
-- cow's milk allergy is more likely to develop in infants whose mothers have relatively low levels of milk IgA antibodies (the antibodies that are specific to mucous linings of mouth through to gut) to bovine proteins; allergic mothers appear to have decreased levels of ovalbumin-specific IgA and elevated levels of Th2-promoting IL-4 in their breast milk (interleukin-4; b-cell stimulatory factor; one of the many genes involved in the cascading reactions of allergy and asthma) (Th2 part of the immune system is the allergic part of the reaction whereas Th1 responds to microbial/viral attack)
the best part of this article is (finally!) a picture of how the interaction schematically works between mama's immune system, her mammary glands, and the child. it seems to suggest that if mama's gut is compromised and her immune system fails to mount a reasonable IgA response to food antigens, then nursing baby will not receive the necessary antibodies to achieve full oral tolerance
Hey Gut Healing Mamas. I hope you don't mind my posting my question here. I think you can help me. I've tried to read through your cheat sheet and this thread to glean some information before posting my question, but it was kinda overwhelming...so...
My younger DD seems very suseptible to stomach bugs. I started a thread about it, then I noticed your thread. Maybe some of you could chime in on how to heal her tummy and build back up some immunity in her stomach?
Or maybe this is just normal for some kids?
What can I do during this time (and after) to "heal the gut" for us both?
|I have a history of IBS since HS. I have been able to manage it with diet - more grains, fruits, veggies, etc less red meats, fats, sugars, etc and by trying to manage my stress - it definitely is linked primarily to stress for me. There is a huge family history of IBS, especially in the women on my mother's side.|
|Plus there is a huge milk allergy/intolerance from my dad's side. Not a big fan of milk, but love cheese and yogurt.|
|DS has had a "sensitive system" since shortly after birth - first he reacted to the antibiotic I was on for a PP UTI - I inisisted he was reacted, only to be told no, it's normal for babies to be colicky. Two weeks later it got to the point that he went 12 hours without nursing, sleeping, and just cried and cried and cried. FINALLY they listened to me, saw him, and decided he was reacting to the macrobid I was taking, and switched me to amoxicillin, which made him feel slightly better (enough to nurse and sleep anyway) and finally kicked my UTI. But it butchtered his stomach. Resulting in months and months (until about 8 months old) of severe colic like symptoms. I treated him with gripe water and probiotics and watched my diet carefully, eliminating anything that seemed to make it "worse" - it seems that his tummy troubles have gotten "better" over time, but he (and I) are still prone to very very sensitive tummies.|
|We held off on introing dairy products, when he did he seemed okay with cheese and yogurt but got tummy troubles with anything else dairy. his eczema got worse over time though, then the runny nose started and hasn't stopped - "it's just from teething" I was told. The sleep disturbances and irritability, "it's just teething" the diarrhea off and on "its just teething" Finally after reading, I decided to eliminate dairy and switched to soy products. It made things worse. He ended up with worse diaper rash, diarrhea more on than off, a constant runny nose, never sleeping soundly, "its just his molars, they are always the worst" Then the ear infection that lasted almost 2 full months. After kicking twice, only to get it back within a few days (using chiropractic care, homeopathic remedies, and finally anitbiotics) I threw out all the soy in my house - it cleared up within a few days and hasn't come back since!|
|Since my ped is an idiot as far as I am concerned at this point, when he reacted to peanuts and she refused to even call in an epipen or get on the phone and answer a few question for this panic stricken but fairly knowledgable mama - we switched. We started with a new doctor that is ancient but wonderful. LOL He doesn't believe in vaxing, was so proud that DS is still BF, proud to hear we do organic foods, and just the doctor of my dreams at this point. He specializes in food and environmental allergies, nutritional medicine, and treating vax damaged kids.|
|He wants an extensive food diary to help us pin point intolerances, allergies, and nutritional concerns.
What else can I do in the meantime? what exactly is "healing the gut" - it seems like diet based and supplements like probiotics from what little I have gotten a chance to read so far, can anyone give me a quick summary or some good links?
There is little safety information available on the effects of herbs in breastfeeding. In general, we look at the actions of herbs to see whether the herb's action would have a negative effect on the health of the mother or baby. Some of the herbal actions that you want to avoid in breastfeeding are the following: herbs that decrease the milk supply (e.g. sage); herbs with hormonal actions that may affect your hormones and therefore your breast milk supply (e.g. licorice); herbs that are stimulating (this may cause overstimulation or sedation of the baby's nervous system or of a particular organ (e.g. bladderwrack stimulates the thyroid gland); herbs that cause digestive distress (e.g. lots of garlic); herbs that are toxic in large doses (e.g. wormwood); herbal laxatives (e.g. senna, Cascara sagrada); herbs that cause an allergic reaction in the mother.
In olive leaf, you do not want the blood pressure lowering or blood sugar lowering actions transmitted to your baby. Without any safety information on the use of this herb with breastfeeding, it may be best to avoid it because of these actions.