on a tissue level - pre eclampsia has certain charteristics Infant and /or maternal spiral arteries do not relax dilate and intertwine so that good exchange can happen- so anything that would change/effect microcirculation- including implantation too shallowly, too deeply, implantation at the right depth but the arteries are already damaged- like in people with metabolic, hypertensive or diabetic disorders -- or for some people immune system triggered against fetal tissues
from studies we can say certain people may be at increased risk- but we can not say for certain who will get pre eclampsia- it is complex with many women who get it in pregnancy and the only risk factor is that it is their first pregnancy-
there are some connections to genetic disorders
- some known risk factors
primip
older or teen pregnancy
group b blood
diabetes
Rh -
pregnancy with multiples- twins, triplets....
chronic hypertension before pregnancy
molar pregnancy
race- black at highest risk in the US
factor V Leiden heterozygote deficiency, activated protein C resistance, homocysteinemia, and antiphospholipid syndrome. women who are heterozygote carriers for β-oxidation disorders, particularly long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency,
renal disease and any chronic disease
even time /season of conception like summer here in the US and Egypt but
in Russia it is winter/spring-
from studies we can say certain people may be at increased risk- but we can not say for certain who will get pre eclampsia- it is complex with many women who get it in pregnancy and the only risk factor is that it is their first pregnancy-
there are some connections to genetic disorders
- some known risk factors
primip
older or teen pregnancy
group b blood
diabetes
Rh -
pregnancy with multiples- twins, triplets....
chronic hypertension before pregnancy
molar pregnancy
race- black at highest risk in the US
factor V Leiden heterozygote deficiency, activated protein C resistance, homocysteinemia, and antiphospholipid syndrome. women who are heterozygote carriers for β-oxidation disorders, particularly long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency,
renal disease and any chronic disease
even time /season of conception like summer here in the US and Egypt but
in Russia it is winter/spring-
