Got It!!
Thank you to the Intellectual Property people, who provide such useful information.
http://www.wipo.int/pctdb/en/wo.jsp?wo=2006097701
"Publication Number: WO/2006/097701 International Application No.: PCT/GB2006/000890
Publication Date:21.09.2006 International Filing Date:14.03.2006
Int. Class.:C12N 5/06 (2006.01), A61L 27/60 (2006.01)
Applicants:INTERCYTEX LIMITED [GB/GB]; Innovation House, Oaks Business Park, Crewe Road, Wythenshawe, Manchester, M29 9QR (GB) (All Except US)."
"Title: SKIN EQUIVALENT CULTURE
Abstract:
Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on a support matrix; (ii) inducing and/or enhancing collagen production by the collagen-producing cells to form a collagenous construct and degradation and replacement of the support matrix; (iii) freeze-drying the construct; and (iv) re-populating the freeze-dried construct with collagen-producing cells and/or epithelial cells and/or endothelial cells and/or mesenchymal cells, thereby forming a connective tissue equivalent, wherein: (a) the collagen-producing cells are substantially fibroblasts; for example human neonatal dermal fibroblasts; (b) the support matrix is a provisional support matrix in which the support matrix is a fibrin matrix, for example formed by thrombin-mediated polymerisation of fibrinogen; and (c) as a result of the collagen production by the collagen-producing cells the provisional fibrin support matrix is digested by the cells and is replaced by collagen, thereby essentially replacing the provisional fibrin matrix with a collagen matrix synthesised in situ by the cells."
and:
http://www.wipo.int/pctdb/en/wo.jsp?...1&DISPLAY=DESC
"Medium components
......."number (p6-pl5) was another parameter tested in our constructs. Similarly, although the constructs were usually composed with HDFs and culture conditions used in the experiments favoured the growth and survival of these cells, it is possible that a component of other cell types might influence the ability of HDFs to make and deposit collagen and other ECM. Normally, the HDFs used in the constructs are derived from human neonatal foreskin. A mixture of cells exist in the intact tissue and in order to isolate the HDFs from the other cell types a combination of enzymatic digestion and growth medium is used to favour outgrowth of HDFs. After six passages, the majority of cells (>90%) thus treated are HDFs. In order to include other potentially beneficial cell types in the constructs, human neonatal foreskins were enzymatically digested to yield a suspension of cells and, rather
than putting these into tissue culture, they were cast immediately into fibrin based constructs....."
http://www.cosmeticconference.co.uk/...Info.asp?ID=43
"Presentation Outline
Intercytex is the world’s leading cell therapy company focussing on skin and hair. It is developing a number of products to replace cells lost from the skin either through disease (chronic ulcers), trauma (acute skin excisions, thermal damage, scars) or aging (hair loss, reduction in skin quality and texture).
The facial treatment is a suspension of cultured allogeneic neonatal human fibroblasts in a defined transport media that provides a 7 day 2-8C shelf life in the clinic. Cultured neonatal human fibroblasts have been used for many years to produce Cosmoderm™ and Cosmoplast™ collagen fillers and the cells themselves have also been used in approximately 200,000 patients to treat a variety of skin disorders with a tremendous safety record. Extensive testing by numerous investigators has shown that these fibroblasts although allogeneic do not illicit an immune reaction even after multiple applications. The reason for this appears to be due to a natural feature of the fibroblast in that they don’t express Class I MHC and only express class II MHC after stimulation but without co-stimulatory molecules that are necessary for T cell activation. This means that these young, metabolically active cells can be used very effectively."
Oh YUK, they really are injecting foreskin cells into old women to remove wrinkles, that is SO gross!
: i wonder if they women who are beautiful again are aware of the price that was paid. its all so very sad and just plain messed up. 
: !
