Out of desperation, we used Colic Calm with DS 1 and we THINK it helped. He was such a high needs baby I never could be sure what combo of things made him feel better. This time around, DD is pretty mellow but she tends to be gasy and spit up so i pulled out that old bottle and gave her some and it works great for her. It's basically charcoal suspended in glycerin and it's considered a homeopathic remedy. One word of warning, the charcoal makes baby poop black. I nearly fainted the first time DS popped but then realized that he just passed the charcoal.