thrombocytosis

[snugglebug14]

I have a doula client with thrombocytosis (high platelets) diagnosed 3 years before pregnancy and untreated. Since finding out she's pregnant she's been taking interferon alpha and low dose aspirin. She is working with a hematologist and the high risk unit OB's at our hospital. But her hematologist know next to nothing about her condition in pregnancy and her OB's know very little about her condition so everyone's kind of walking on thin ice and weary about what labor/birth will bring. Has anyone has experience with this condition in pregnancy? Or has any resources to offer? The stuff I find does not seem promising and shows a high rate of stillbirth due to placental infarction.

(If it helps her pre-pregnancy platelets were over 2 mill/ul and are currently 800,000. Prior to pregnancy they were giving her IV iron supplements to rule out iron deficiency as a cause. her current hct is 26)

Thanks so much for any information anyone has.

[mwherbs]

here is an article on emedicine with a mention on pregnancy--

http://www.emedicine.com/MED/topic2266.htm



"Some reports show patients with an acquired deficiency of antithrombin III, protein C, and protein S"
this quote from the article causes me to wonder about increased green veggies for the anti-clotting factors that they provide... in recent studies on anti-coagulant therapy they are getting better results by not limiting but ensuring a certain amount of vitamin K/day less fluxuations with the meds--

did she have surgery or some sort of illness flare up just before this happened? inflammation can be a cause--

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and because I have gluten intolerance I feel that I should mention this and send along an article- celiacs/gluten intolerance can be a cause --

here is the primary quote from that article that has to do with thrombocytosis-- and below is the link if you want to access it and look at the references-- the easiest way to deal with celiacs is to just stop eating gluten foods- if it works fine if not- oh well not much lost and nothing invasive done---

"Thrombocytosis in association with CD appears to be more common than thrombocytopenia, occurring in up to 60% of patients.78–81 The exact etiology of the thrombocytosis is unknown but it may be secondary to inflammatory mediators or, in some cases, secondary to iron-deficiency anemia or functional hyposplenia.82 The thrombocytosis may resolve after institution of a GFD.79,80"

http://bloodjournal.hematologylibrar...full/109/2/412