I'm on several groups where this is happening. It's basically the same as what I have to do as a bilingual homeschooler, although English is my first language. Language arts and math we do in Spanish. Science, read-alouds (and other books) are done in both languages. (basically a dual-language homeschool) For the first ~two years of her life, I spoke only English to her, and my dh Spanish, but as she got older, we found I needed to switch to my second language. It works fine for our family. Well, we'll see how I feel about teaching 5th grade math in Spanish in a couple of years, lol.
In the yahoo groups I belong to, there are many families where English is the second language and they homeschool in both. There is one family in particular (I've lost contact with her though) that live in Mexico (native) and she also homeschooled in both. She wanted her children to have a good speaking, reading, and writing knowledge of English- her second language.
So, yes it is doable. It becomes practical after a certain point in the multilingual journey to not use OPOL 100%, unless your spouse will be helping homeschool in the other language.
I hope this is helpful.