Anyone do any testing?

[LotusBirthMama]

Hi. I'm curious if any one here has gone through any kind of testing to see what (if any) the issues are? I've had three m/c in the last ten months. I'm feeling that I may have some kind of hormonal issue. All my losses were before the placenta took over...

Any one deal with this?

[IansMommy]

I'm so sorry to hear of your losses. This is my first post in this forum of MDC--although I often lurk because of my own past miscarriage. I lost my baby at 13 weeks on Mothers' Day of 2001. We had testing done, because it had taken us 2 years to conceive. My baby was a girl, and had Turner's Syndrome (if I remember correctly, it is called XO syndrome and only happens in females). It is a chromosome problem, but is random, not genetic. We didn't have to worry about it repeating. My doc (at the time) said that most XO babies survive pregnancy, birth, and live a short life. She thinks I might have miscarried because I have low progesterone in the first trimester of my pregnancies. With my other two, I was put on progesterone immediately.

The testing very much helped me grieve. After more than two losses, I would really consider it. Good luck and stay strong.

[sarah9774]

I was given a panel of tests icluding Lupus and tested for clotting disorders. I have a clotting d/o called Prothrombin Factor II mutation. I am taking 4 mg folic acid plus baby aspirin and everyday, plus PN vitamins, and once I have a positive pregnancy test I will be taking lovenox shots daily. The tests require about 11 viles of blood. There is a link somewhere around here that has the recommended panel. Sounds like you would be a good cand. for these test.. people with certian clotting d/o have issues carring full-term babies without treatments.. Hope this helps..

[honeybeedreams]

i found the information on this page very interesting....

http://www.babyhopes.com/articles/luteal-phase-defect.html

i plan on charting very carefully this time.

HTH!

[taradt]

I had 3 losses that were all very different (one in each trimester). I was tested for antiphospholified (sp) after the first. Our second we ended up testing before he was born, he had trisomy 9, which is very rare and they figured random. After my 3rd loss I knew I needed to do something but wasn't eligable for all the testing so I did a bunch of research and came up with the most likely for my senario, I got tested and found I had high homocysteine levels which could have accounted for all the losses as well as the pre eclampsia I had with my daughter. There is no conclusive evidence on any of the studies they have done on high homocysteine but it made sense to us. We are treating it now and hoping for the best.

good luck to you

tara

[lestouffer]

My babies are the most tested kids in the world! But first, I digress. Turners syndrome is indeed XO (meaning that she got one X chromosome from a parent, baby girls are XX, biys are XY, but the other sex chromosome was missing). I know at least 2 adults with Turners, one has Turners mosaicism meaning HE (after a gender reassignment surgery, kind of) is actually XYXO (meaning half his cells are male and have are Turner's females) raised a girl, now a dad with 2 children (both sperm donated). And not to scare you, but when my first son was diagnosed with DW, they told me it was a fluke and not genetic too, but I have since had another one, you might want to see if someone can test you, just so you know. Still looking for genetic resons for my problems.

My first son had a routine amnio after they realized his problems to see the extent (to see if he had any chromosome anomolies) of his diagnosis. He was still born at 22 weeks. Not becuase of the amnio. Then when I got pregnant again, since they told me it was a fluke, I had no genetic testing done, but a level 2 u/s (you can see the u/s jiggling when they told me that her brain was normal and I broke into sobs). Then when they diagnosed the next one with DW, we ran extensive tesing on his remains (he too s/b at 22 weeks) still with no genetic answers, but clearly thinking it was a boy thing. Had a CVS done on my youngest to ensure she was a girl.

I highly recommend genetic testing. Especially in the cases of being able to do something about it. Like take meds to ensire teh proper environment for teh little ones....

[HoosierDiaperinMama]

Piping in here late, but since I am pg again I have had to get the blood clotting disorder tests. I had 15 vials of blood drawn and the tests were as follows:
Anticardiolipin (3 different tests for that)
Lupus Anticoagulant
Factor V Leiden
Prothrombin Gene Mutation
Antithrombin III Activity
Protein C Activity
Protein S Activity
MTHFR
Homocystine
Glyroprotein II
A1 vs A2 Polymorphin
PAI-1 Gene Mutation
PAI-1 Activity

I should be hearing from my dr. this week as to what the results were. She is highly specialized and the hospital she works for is deep in research about which clotting disorders are related to placental abruptions (what happened to my daughter) and first trimester losses. They are getting closer and closer.

Pending the results, we'll know better how to treat this pregnancy. So far I am taking prenatals and a baby aspirin. I do have one healthy child so it's proof that I can have a living child. Unfortunately, what happened in Reagan's pregnancy was like lightning. I hope that these blood results give us something to go on. We did not have an autopsy done on Reagan but the placenta is preserved and my dr. is hoping to get her hands on the blocks as that specific hospital has 2 of the top pathologists in the nation working for them.

[SoCaliMommy]

I had two m/cs in a row on in April05 at 5wks then got pg again before gettin a AF back and the baby stopped growing at 6wk4day but stupid doctor didnt beliveve me at my 1st u/s at what was 10wks and i didnt start bleeding til 11wks gestation and finally passed the baby at what should have been 13wks gestation*july05*. i tried to get blood work done back in Aug 05 and was told & i you already have a child its not necessary:irked: :irked:

with my 2nd m/c they tested the tissue i passed and the only testing was microscopic which showed nothing abnormal .