Peanut oil as an adjuvant - Mothering Forums
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#1 of 16 Old 06-07-2005, 01:53 AM - Thread Starter
 
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I'm having trouble finding info on this anywhere on the web other than "vax sites".
Can anyone help me out?
I got to thinking about it when I was reading about how the Chinese consume peanuts in a very similar way to Americans, but peanut allergy is almost nonexistant over there. Also, first generation Chinese immigrants immidiately become as likely as Americans to develop the allergy. (I read this on an non-vax related allergy website.)

Kind of as a side note, I thought this was interesting.
http://www4.nationalacademies.org/ne...1?OpenDocument
Quote:
The committee looked at five studies examining multiple vaccinations and their potential to cause allergic diseases, which reflect a hypersensitivity of the immune system to relatively harmless agents in the environment, like pollens, dust mites, insect venom, and specific foods. Some, but not all, of these studies suggested that certain vaccines increase the risk of developing allergic disorders. Methodological weaknesses and inconsistent findings among the studies, however, led the committee to conclude that there is inadequate evidence to either accept or reject a causal relationship between multiple immunizations and increased risk of allergic diseases, particularly asthma.

Although the committee's review of clinical and epidemiological studies found no link between childhood immunizations and immune system dysfunction, its evaluation of basic science research yielded weak evidence of biological mechanisms by which vaccinations might increase the risk of diabetes or allergies. However, there is strong evidence of mechanisms by which vaccinations could increase the risk for infections. While such biological evidence can never prove causality, it can guide further investigation.
I haven't read the full version yet, but will probably do that later...
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#2 of 16 Old 06-07-2005, 10:59 AM
 
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I can't give you any references either. Maybe you could call up the FDA?

But I did read about a Swiss study that was done by Dr. Rolf Zinkernagel (Nobel Price Winner) with white mice. It showed that when they were injected with ANY foreign protein (such as we get in vaccines) the mice had allergies from then on.
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#3 of 16 Old 06-07-2005, 11:05 AM
 
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Could you maybe rephrase what you're wondering - I don't think I understand what you're asking.
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#4 of 16 Old 06-07-2005, 04:03 PM - Thread Starter
 
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Originally Posted by amnesiac
Could you maybe rephrase what you're wondering - I don't think I understand what you're asking.
I'm looking for information showing which commercial adjuvants use peanut oil (as opposed to mineral oil or aluminum) to trigger an immune response.
All I'm finding on google are sites like "vaxlib", who's integrity I don't doubt, but I'm looking for outside confirmation, yk?
I'm also finding what appears to be good info, but they're wanting money to see it. :
I'm wondering when they started using peanut oil, and how that date might correlate with the emergence of the allergy.
It's just too odd that docs say "vaxes don't cause peanut allergy. The allergy is probably caused by an increase in exposure to peanuts at an earlier age."...all the while injecting babies with peanut oil to specifically create an allergic reaction. :
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#5 of 16 Old 06-07-2005, 04:38 PM
 
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Well the aluminum adjuvants are the only ones licensed for use in licensed human vaccines. Off the top of my head I don't know where, but look over at the FDA to verify that info. Sometimes other things are used in research though.
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#6 of 16 Old 06-07-2005, 04:41 PM
 
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Also try this - do a search over at PubMed for "adjuvant 65"
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#7 of 16 Old 06-07-2005, 05:08 PM - Thread Starter
 
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Quote:
Originally Posted by amnesiac
Also try this - do a search over at PubMed for "adjuvant 65"
Thanks!
Ok...so it's Merck65 that is made with peanut oil.
This is a kind of stupid question, but is there any way to get *in* to Pub Med?
All I can get are those dinky little paragraphs...Is there a way to access the full articles through Pub Med, or do I need to look elsewhere for the unabridged versions?
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#8 of 16 Old 06-07-2005, 05:16 PM
 
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Try your library.I would get the full copy of articles for free(ask, as some charge).
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#9 of 16 Old 06-07-2005, 05:23 PM
 
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If it's Hilleman, it's Merck. So far as I can tell it was only used briefly in research & abandoned after flu vax trial in the 60s-70s.

Getting the full text:
http://www.ncbi.nlm.nih.gov/entrez/q....html#Ordering
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#10 of 16 Old 06-07-2005, 09:27 PM - Thread Starter
 
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I've also found some product patented thru Matrix that has a peanut oil adjuvant component.
http://spore.patentmatrix.com/Projec...5C5753234.html
I don't know what this is used for, though....might be a vetrinary thing.
ETA...or is that a format for creating a patent?
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#11 of 16 Old 06-08-2005, 11:10 AM
 
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That number up at the top is the patent number. The patent holders are a group at LG Chemical (actually LG Life Sciences) in Korea. Their pharmaceutical division makes some vaccines for use over there but I don't believe they use that patented deal:
Euvax B Injection
Influenza Ha Vaccine Injection
Japanese Encephalitis Vaccine Injection
LG Vi Typhoid Vaccine Injection
Varicella Vaccine

That patent is for a "single shot" system, meaning you don't have to get repeated shots - one time makes lots more antibodies than regular vaxes.
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#12 of 16 Old 06-09-2005, 04:08 AM - Thread Starter
 
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How did you find that, Amnesiac?
Lol...and I thought my internet skills were pretty good...
Anyway, I'm giving up on the peanut thing, I guess. I found some references to peanut oil being a protein coat in the HiB, but those were just allusions to it, lacking solid data.
Anyway, what do you think of this?
(completely different matter...just decided to post it here instead of creating another thread).
http://ajp.amjpathol.org/cgi/content/full/163/4/1623
I know this adjuvant isn't used in humans any longer, as well, but it seems it was at one time, and wasn't known to be as...potentially encephalitically causitive (yeah, I know I just made up a new word...lol...but you get the drift) as it's known to be now.
For quite a while I've been unnerved by the similaritites in "normal vax reactions in infants" and encephalitis.
From the sleepiness to the weird crying to the fevers to the glazed looks in their eyes, the two seem nearly identical.
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#13 of 16 Old 06-09-2005, 06:14 AM
 
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Quote:
I got to thinking about it when I was reading about how the Chinese consume peanuts in a very similar way to Americans, but peanut allergy is almost nonexistant over there. Also, first generation Chinese immigrants immidiately become as likely as Americans to develop the allergy.
I had always thought that it was caused by using peanut oil in infant formula.
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#14 of 16 Old 06-09-2005, 10:44 AM
 
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I had always thought that it was caused by using peanut oil in infant formula
Well that makes perfect sense! I never even thought of them doing that!


Quote:
How did you find that, Amnesiac?
I just guessed it was a patent number & entered it over at the US patent office. Then when it pulled up I looked up the company.


Quote:
For quite a while I've been unnerved by the similaritites in "normal vax reactions in infants" and encephalitis.
That's why we now have DTaP. Back in the DTwP days, encephalitic reactions happened extremely frequently but moms were told that it was just an expected part of it. But anyhow, that's not something that's limited to vaccines containing adjuvants. For example, if you read the MMR insert you'll see it lists encephalitis & encephalopathy as adverse effects.
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#15 of 16 Old 11-29-2005, 07:07 AM
 
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Quote:
Anyway, I'm giving up on the peanut thing, I guess. I found some references to peanut oil being a protein coat in the HiB, but those were just allusions to it, lacking solid data.
From the University of Texas Medical Branch:

Quote:
Vaccines also sometimes contain adjuvants, substances that enhance the immunizing potential of the vaccine. Peanut oil and aluminum salts are sometimes employed as adjuvants.
http://euclid.dne.wvfibernet.net/~jv...nology_II.html
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#16 of 16 Old 11-29-2005, 12:05 PM
 
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thanks for that link dinogirl
i had to laugh at their table, it says the MMR vax produces lifelong immunity.
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