Join Date: Apr 2005
Location: Lafayette, IN
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|Hmmm... it may have to do with how it works then. I know that the IPV doesn't prevent transmission either (virus instead of bacteria of course, so whole different creature...)|
Do you have info about this? I'd be interested to learn more about this. I thought all vaccines were suppose to prevent transmission... Thanks!
|Inactivated polio vaccine (IPV) needs to be injected and works by producing protective antibodies in the blood (serum immunity) - thus preventing the spread of poliovirus to the central nervous system. However, it induces only very low levels of immunity to polivirus locally, inside the gut. As a result, it provides individual protection against polio paralysis but, unlike OPV, cannot prevent the spread of wild polio virus.|
Here is the package insert which in the very first sentence says that it's Diptheria toxoid and Tetanus toxoid, but Pertussis bacteria (acellular because the old whole-cell bacteria was thought to be the cause of the adverse reactions in the DTP vaccine; that's what the "a" in DTaP stands for) It appears that Connor's dr was right, the pertussis portion of the vaccine DOES protect against the bacteria, so in theory SHOULD prevent transmission.
|INFANRIX (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) is a noninfectious, sterile combination of diphtheria and tetanus toxoids and 3 pertussis antigens [inactivated pertussis toxin (PT) and formaldehyde-treated filamentous hemagglutinin (FHA) and pertactin (69 kiloDalton outer membrane protein)] adsorbed onto aluminum hydroxide. INFANRIX is intended for intramuscular injection only.|
I'm crunchy... Like a Dorito.
Mama to Sprout 4.09 and Bruises 7.11 handfasted to 9.07
they are pieces of Pertussis.
Pertractin is the "house" or outer membrane protein that sticks to epithelial cells. FHA is the tendril that grabs on. "it is a fimbrial-like structure on the bacterial surface, and cell-bound pertussis toxin (PTx). Short range effects of soluble toxins play a role as well in invasion during the colonization stage."
http://www.textbookofbacteriology.net/pertussis.html for FHA Pertractin, just google for a refrence
|Characterization of Bactericidal Immune Responses following Vaccination with Acellular Pertussis Vaccines in Adults|
|Similarly, opsonization with the postimmunization sera failed to enhance attachment or phagocytosis of bacteria by neutrophils, and one postimmunization sample with a strong response to filamentous hemagglutinin caused an inhibition of phagocytosis that was statistically significant compared to that observed for the no-serum control. In summary, booster immunization of adults with acellular pertussis vaccines was not found to increase bactericidal activity over preimmunization levels. Identifying ways to promote bactericidal immune responses might improve the efficacy of acellular pertussis vaccines.|
|Neutralizing Antibodies to Adenylate Cyclase Toxin Promote Phagocytosis of Bordetella pertussis by Human Neutrophils|
I think most of us can agree here that the pertussis vax does not prevent transmission.
However doesn't it prevent some transmission? If you have pertussis but no symptoms you're much less likely to spread germs. You're not coughing all over the place, nose running, etc.
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