A fruiend just popped onto messenger and asked if I would post here for some info. I said sure!
She'd like to know about the aluminum in Prevnar mainly but everything about it as well. She'd like it in easy terms. She went to their site and said it was all over her head. ANY and all information is what she wants!
Prevnar manufacturer's package insert: http://www.wyeth.com/content/ShowLabeling.asp?id=134
ACIP Recommendation (1997): http://www.cdc.gov/mmwr/preview/mmwrhtml/00047135.htm
It's hard to put into simple terms. This is simple to me, but it won't be to her, therefore her best option is to sit down, concentrate and determine that she will get her head around basic principles which are these.
Aluminium is put into vaccines, because without it, the body will not react to weak strains of antigens. Aluminium is highly reactive, and is a Th2 "skewer". This is the whole reason why aluminum is added to vaccines.
(Yes she may well have to look them up and do a bit of learning, but what is wrong with asking her to do that? She's the one that wants answers.)
These cells are the antigen presenting cells.
They won't react to just, say, "pertussis" or "pneumococcus" on its own. The Aluminium, wakes up, and locks these antigen presenting cells in the 'on' postition. It also creates more APC's (antigen presenting cells), which is the whole point, because without extra APC's, the vaccine won't provoke antibodies, because the bacteria hasn't got there via normal portals of entry i.e. throat / Waldeyer's Ring (tonsils etc)...
But these eextra APC's can also cause a big problem. Take SLE for example (Systemic lupus erythematosus)
Researchers know that for some reason dendritic cells present antigen for too long and this allows abnormal antibodies to be produced: autoantibodies. Most SLE researchers think it is because of some genetic reason but it could also be aluminum. Antigen presenting cells from vaccines exist solely to promote an immune response: aluminum ensures that it is an abnormal response.
She needs to understand what aluminium can and does do in the body to see how it might act. That is very dependant on the individual immune system, and the nutrition of the person.
Interestingly macrophages are affected by aluminum as well. They become loaded with aluminum particles and this disrupts their function. When macrophages cross the blood brain barrier they take the aluminum with them.
Aluminum can integrate into molecular functions but it is first and foremost a neurotoxin. Which is why the affinity for the brain and when it gets there it demyelinates neurons. When that happens you get all the symptoms of multiple sclerosis.
Aluminum also alters the permeability of the blood-brain barrier making the brain more accessible to other toxins in the body that you don't want in there. If you have flouride in your water, the combined toxicity is much higher again...
So. Aluminum invades certain cell types, especially monocytes and macrophages. It critically alters their function in a way that is extremely harmful to the person affected.
Aluminum hydroxide in vaccines is highly reactive and separates spontaneously. And since it is injected through the skin right into your tissue it is instantly absorbed and enters the brain. It’s not just a potential risk with vaccines – every AlOH injection puts aluminum right into your brain – every single one. The only known cause of MMF (Macrophagic myofasciitis) is aluminum adjuvanted vaccines. And fully one third of MMF cases develop into multiple sclerosis.
Gherardi et al. 2001 Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle. Brain, 124:1821-1831
[If you read only one paper about aluminum this should be it.]
Redhead et al. 1992. Aluminum-adjuvanted vaccines transiently increase aluminum levels in murine brain tissue. Pharmacology and Toxicology, 70:278-280
[Aluminum from vaccines enters the brain almost immediately after it is injected. Also, measurable amounts of aluminum are present at the injection site for up to 8 years after vaccination.]
After you understand that aluminum from vaccines will always enter the brain, these make for good reading:
Yokel. 2000. The toxicology of aluminum in the brain: a review. Neurotoxicology Oct;21(5):813-828
[This paper reviews all the ways that Al affects the brain. It is not about vaccines. Also you could just do a medline search on aluminum and brain and you will find literally a ton of papers describing the adverse effects of Al on the brain. Al is a very potent neurotoxin if it can gain access to the brain.]
Verstraeten et al. 1997. Myelin is a preferential target of aluminum-mediated oxidative damage. Archives of Biochemistry and Biophysics, 344(2):289-294
[Myelin is the protective protein that coats neurons and covers the spinal cord. Damage to this protein is referred to as demyelination. Multiple sclerosis and autism are prime examples of demyelinating diseases where damage to myelin causes neurological dysfunction.]
Campbell et al. 2000. Aluminum-induced oxidative events and its relation to inflammation: a role for the metal in Alzheimer’s disease. Cellular and Molecular Biology, 46:721-730
[Alzheimer’s is not a genetic disease. It is an age-dependent response to accumulated heavy metal poisoning.]
MT, since you are on this topic already, can you tell me what you think about this? my 14 mo dd had one vaccine, the hib, at 7 mos old. she had a huge huge welt (size of a walnut) at the vaccine site for over 2 months. could this have been a reaction to the aluminum or other ingredients in the vaccine? would you recommend her having any other vaccines? (i have had a bad feeling about her reaction to that vax and haven't been able to stomach the idea of giving her any more). thanks.
Yes, those nodules are pretty common in response to aluminum adjuvants.
There's lots of aluminum info in this thread:
Prevnar & aluminum easy language article:
My "easy" thoughts on aluminum,
it is highly suspected the aluminum in vaccines causes vaccine sarcoma in cats
sarcoma: A malignant tumor arising from connective tissues.
Of the three FeLV vaccines tested, the aluminum-containing vaccine most consistently induced local inflammation at the vaccine site, followed by nonaluminum-adjuvanted FeLV vaccines, which caused measurable reactions in only one of six vaccinated cats. No measurable local inflammation was evident at the nonadjuvanted FeLV vaccination sites.
Dr. Macy also investigated whether administering vaccines intramuscularly or massaging the vaccination site after administration impacted inflammation. Some veterinarians have suggested that vaccines administered intramuscularly do not induce tumors and that massage immediately after a vaccination may prevent subsequent tumor development. Dr. Macy says he did not observe a significant reduction in inflammation when a vaccine was administered intramuscularly. He also found that massaging a site only changed the shape but not the volume of the inflamed area.
"Aluminum hydroxide is a common component of feline vaccine adjuvants and many pathologists consider this material to be the most definitive evidence that a feline sarcoma is vaccine-associated."
are we really that much different than cats?
aluminum is a neurotoxin
neurotoxin: A toxin that damages or destroys nerve tissue.
Vaccines bypass the first lines of immune defense, which is why the aluminum is needed to jumpstart the immune response, hence the term adjuvant.
adjuvant: A pharmacological agent added to a drug to increase or aid its effect.
My "easy" thoughts on Prevnar vaccine:
It's a new vaccine, just licensed in 2000. How did we ever survive without it? Read the vaccine insert, it may be all the info your friend will need for that one, it can be obtained at her dr's office per request. Advise your friend to carefully observe dr's behavior when this request is made, and at how quick and/or easily this request is responded to.
Also, when testing in clincial trials, the "placebo" was another vaccine, so not much good info there as far as adverse reaction rate. I did read there was a higher rate of fevers and seizures when compared to other vaccines. You just have to wonder what the seizure/fever rate was in the unvaccinated ...we may never know.
Multiple times throughout childhood this jumpstart via aluminum is performed on our children. What is the impact of attempting to trick the immune system so often and with aluminum et al?
More questions your friend will need to find answers for.
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