sm ~ the title of the thread is vaccines and autism. the discussion is, is there any pathway by which rubella could cause autism.
there is. it's immunological.
doing a search of your posts, using key words, you suggest "expertise" in medicine aka your user name.
so asking me this question: *** Do you know if the difference between the vaccine reaction demyelination and natural infections was ever been followed long term? *** seems odd.
you will know the answer to that question.
you also ask *Have you ever seen the movie Lorenzo's Oil?*** answer, yes, but that has nothing to do with demyelination from virus or vaccine.
you then refer to me saying this: ***anything that can cause encephalopathy, or demyelinate, can cause autism. by the same token, any vaccine of a virus that can do that in an infection can in susceptible kiddos do the same thing.***
and you ask ***Can you add any more information to this statement?***
what more needs to be added? if you are a science mom you know the words biological plausibility. if you want to look at all the possible mechanisms properly, you will know you can't stop with demyelination. you might want to add disseminated vasculomyelinopathy to the storyline, coz it often goes along with demyelination. start with an old paper by charles m poser, acta neurologica scandinavic 1969, then work forwards.
then you say *** You are not discussing CRS induced teratogenesis for it is rather difficult to mount an autoimmune response without a functional immune system; elementary really.***
interesting. recent research (done to justify vaccinating mothers in pregnancy) alleges that intrauterine fetuses have a far more mature and more functioning immune system than previously thought. presumably you know of that research as well.
you are right. it wasn't me discussing teratogenesis. you are the one who got side-tracked onto organogenesis. the title of this thread is vaccines and autism isn't it? teratogenesis has nothing to do with autism.
*** I believe you are referring to acute disseminated encephalomyelitis (ADC) and there are much better references for it that were conducted in this century. ***
a kiddo doesn't have to have ADC to have demyelination. it can be subclinical. and if measles also can have the same effect, then the problems could be worse. also with kiddos, the process of myelination is the important factor. you are the science mom. tell me sm. when does a kiddo's brain finish myelinating? (yes, i know the answer) what might happen if you give a kiddo a shot when their brains aren't myelinated? and if they have an immune system problem? or are stressed?
you say ***The clinical profile for ADC is quite profound as is the immunological profile and patients respond to corticosteroid therapy quite well. Again, if what you are implying has been responsible for autism then the so-called epidemic would have been observed beginning in the mid 1960's and every rubella epidemic prior to that. Rubella disease post-natally does not cause autism so how do you propose that the vaccine does?***
what about the subclinical profile? rubella as a virus, in a child, can cause demyelination, and encephalopathy. encephalopathy can result in autism. any virus which can result in demyelination and encephalopathy (and vasculomyelinopathy), and therefore autism, when made into a vaccine, and combined with other viruses, can in a susceptible child, theoretically cause autism.
not rocket science.
even horse breeders understand these concepts.