Please lodge anti-circ replies with the DHHS (re: 2013 Viral Hepatitis Action Plan). Deadline 5 July 2013. - Mothering Forums

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#1 of 4 Old 06-26-2013, 06:39 AM - Thread Starter
 
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This is a response to the document "2014 Viral Hepatitis Action Plan" [FR Document Number: 2013-13332].

The deadline for submissions is 5 July 2013.

This submission can be made by anybody from any country around the world.

Instructions:

Download and save the document from the following link (Click 'Download'):

http://www.2shared.com/document/p89sEQZM/2014_Viral_Hepatitis_Action_Pl.html

Email the document to Corinna.Dan@hhs.gov with the subject heading "2014 Viral Hepatitis Action Plan".
 

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#2 of 4 Old 06-26-2013, 06:40 AM - Thread Starter
 
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In case anyone experiences problems with the above 2shared link, the full-text of the response document is below, which you can copy/paste into the text-editor or wordprocessor of your choice, save to your harddisk, and email to Corinna.Dan@hhs.gov -



U.S. Department of Health and Human Services
200 Independence Ave. SW.
Room 443-H
Washington, DC 20201
Attention: 2014 Viral Hepatitis Action Plan

Thank you for the opportunity to provide feedback to the 2014 Viral Hepatitis Action Plan [FR Document Number: 2013-13332]. This response document will briefly address the special danger posed to newly circumcised baby boys from acquiring transfusion-transmitted hepatitis B virus [HBV] infection.

Transfusion-transmitted HBV infection

HBV remains a major risk of transfusion-transmitted infection due to the pre-seroconversion window period, infection with immunovariant viruses, and with occult carriage of HBV infection (Candotti & Allain 2009). Recipients of blood transfusions in the U.S continue to be at risk for HBV infection as a result of breakdowns in basic infection control and limitations in the laboratory screening of donated blood (HHS 2011). Blood transfusions were the fifth most common procedure received by children and infants in U.S hospitals for the year 2009, with approximately 109,400 transfusions being administered (AHRQ 2011). Prophylactic HBV vaccine was received by less than 1.33 million infants in the year 2009 (AHRQ 2011), out of approximately 4.13 million births for that year (CDC 2011a). Indviduals infected with transfusion-transmitted HBV can latter become carriers of the virus in the general community (HHS 2011). While over 95% of people infected as adults will spontaneously clear the HBV virus, this reduces to 30% in children, and 5% in infants (Bell & Nguyen 2009). Untreated, chronic hepatitis B acquired early in life results in cirrhosis, liver failure, or hepatocellular carcinoma in up to 40% of individuals (Weisberg et al 2007).

Circumcision and haemophilia A as special risk factors for acquiring transfusion-transmitted HBV infection

Circumcision of male minors, in the absence of a clear and present immediate medical indication, is a controversial practice within the medical profession (KNMG 2010; Smith 2011). Despite this, more than 1.14 million circumcision procedures were performed on male infants in U.S. hospitals in the year 2009 (AHRQ 2011). One of the commonest complications of circumcision is excessive bleeding and rates as high as 35% have been quoted in the literature (Mahomed et al 2009). Babies often present after several hours of continued bleeding and blood transfusion may be necessary (Qazi et al 2010).

A survey conducted by Ragni et al (2011) of current prophylaxis practices and bleeding characteristics of children with severe haemophilia A in U.S. haemophilia treatment centres [HTCs], found that among 226 newborns with severe haemophilia A in 62 HTCs, the median age at first bleed, excluding circumcision, was 7 months and that of the 113 [53.5%] newborns who underwent circumcision, 62 [54.9%] bled. Haemophilia A occurs among approximately 1 out of every 6,250 male births (CDC 2011b). Although lower than in the past, HBV infection remains a risk among those with haemophilia A who rely on blood products to counteract the disease (Steele et al 2009).

Thus, a higher proportion of boys are already at greater risk of acquiring transfusion-transmitted HBV infection relative to girls, and circumcision worsens that disadvantage.

Action Required

Genital integrity [non-circumcision] is most likely to produce the highest state of health and well-being and is the preferred medical option for newborn boys (KNMG 2010, Van Howe 2004).

Public health officials should act to suspend the performance of medically-unnecessary non-therapeutic circumcision of boys.

Hospital administrators must respond to this threat to all children and especially circumcised boys by limiting circumcisions to those for which there is a clear and present immediate medical indication.

References:

AHRQ (2011) Hospital Stays for Children, 2009. HCUP Statistical Brief #118 prepared by Yu, H. (RAND Corporation), Wier, L.M. (Thomson Reuters), and Elixhauser, A. (AHRQ) August 2011. Agency for Healthcare Research and Quality, Rockville, MD Full-text available at http://www.hcup-us.ahrq.gov/reports/statbriefs/sb118.jsp

Candotti & Allain (2009) Transfusion-transmitted hepatitis B virus infection J Hepatol. 2009 Oct;51(4):798-809. Epub 2009 Jun 10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19615780

CDC (2011a) Births: Final Data for 2009 in National Vital Statistics Reports Volume 60 Number 1 Prepared by Joyce A. Martin, M.P.H.; Brady E. Hamilton, Ph.D.; Ph.D.; Stephanie J. Ventura, M.A Michelle J.K. Osterman, M.H.S.; Sharon Kirmeyer, PhD.; T.J. Mathews, M.S.; and Elizabeth Wilson M.P.H., Division of Vital Statistics Full-text available at http://www.cdc.gov/nchs/data/nvsr/nvsr60/nvsr60_01.pdf

CDC (2011b) Hemophilia Facts Centers for Disease Control and Prevention Full-text available at http://www.cdc.gov/ncbddd/hemophilia/facts.html

HHS (2011) COMBATING THE SILENT EPIDEMIC of VIRAL HEPATITIS Action Plan for the Prevention, Care & Treatment of Viral Hepatitis United States Department of Health & Human Services Full-text available at http://www.hhs.gov/ash/initiatives/hepatitis/actionplan_viralhepatitis2011.pdf

KNMG (2010) Non-theraputic circumcision of male minors Royal Dutch Medical Association Full-text available at http://knmg.artsennet.nl/web/file?uuid=579e836d-ea83-410f-9889-feb7eda87cd5&owner=a8a9ce0e-f42b-47a5-960e-be08025b7b04&contentid=77976

Mahomed A, Zaparackaite I, Adam S (2009) Improving outcome from Plastibell circumcisions in infants Int Braz J Urol. 2009 May-Jun;35(3):310-3; discussion 313-4 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19538766

Qazi A, Haider N, Crabbe D (2010) A simple technique to control bleeding after Plastibell circumcision Ann R Coll Surg Engl. 2010 Apr;92(3):261-2 Full-text available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080088/

Ragni MV, Fogarty PJ, Josephson NC, Neff AT, Raffini LJ, Kessler CM (2011) Survey of current prophylaxis practices and bleeding characteristics of children with severe haemophilia A in US haemophilia treatment centres Haemophilia. 2011 May 4. doi: 10.1111/j.1365-2516.2011.02554.x. [Epub ahead of print] Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21539695

Smith JF (2011) The professional imperative for obstetrician-gynecologists to discontinue newborn male circumcision Am J Perinatol. 2011 Feb;28(2):125-8. Epub 2010 Aug 10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed?term=20700861

Steele M, Cochrane A, Wakefield C, Stain AM, Ling S, Blanchette V, Gold R, Ford-Jones L (2009) Hepatitis A and B immunization for individuals with inherited bleeding disorders Haemophilia. 2009 Mar;15(2):437-47 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19335752

Van Howe RS (2004) A cost-utility analysis of neonatal circumcision Med Decis Making. 2004 Nov-Dec;24(6):584-601 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/15534340

Weisberg IS, Brown RS Jr & Sigal SH (2007) Hepatitis B and end-stage liver disease Clin Liver Dis. 2007 Nov;11(4):893-916, ix Abstract availabe at http://www.ncbi.nlm.nih.gov/pubmed/17981234

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#3 of 4 Old 06-28-2013, 09:34 PM - Thread Starter
 
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Final week for lodging submissions.

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#4 of 4 Old 07-05-2013, 05:06 AM - Thread Starter
 
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Last day for lodging submissions.

To be sure, this is the last "Call to Action" post on a purely domestic U.S. health issue that I'll be leading.

I should have butted-out earlier, but we already had plenty of information archived over at F-R.net about haemophilia, excessive bleeding following circumcision and transfusion-transmitted HBV, neatly summarised from an earlier Call to Action post so the temptation to lead one last post was too great.

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