After two m/c, I asked my midwife to test my progesterone asap with this pregnancy and was/am willing to supplement in hopes that it would help. I had a level of 5 at 17 dpo, so definitely felt like this was worth trying. My first positive test was May 25. Hadn't had any cramping or spotting, still haven't.
After three days of haggling with my insurance to get the medicine covered, I took the first dose of Crinone last night and read through the info pamphlet - risks to the fetus include cleft palate & abdominal wall defects. Time for me to freak out; I born with a cleft and my kids have an increased risk already because of that.
Then I kept reading and realized that the studies mentioned on the pamphlet involved less than 50 women! One of the babies had a cleft palate. How on earth is that supposed to guarantee product safety? Today I started googling and was reading some OBs comments re: safety, one said that since the 50 women in his practice that used it had no ill effects it's probably fine. Another actually said that the risk of a cleft is not that big of a deal because "they are so easy to fix nowadays". Right. Because repeated surgery isn't difficult for a small child...
It is possible that that one cleft palate had nothing to do with the hormone, but what I'm wondering is if any of you have heard of larger studies involving this drug.
Thanks in advance!