High BP, anyone have experience w/ meds
I Had pre-e in the past and was on metoporol while not pregnant but honestly I wasnt good about taking it (bad bad i know) So I havnt seen my OB yet, I see her on the 6th, my family doc says to take the metoporol but then i did a bunch of reading and it scared the CRAP out of me. I'm afraid to take it now. Should I wait to take it til I see and talk to the OB? or go ahead and take it til then (BP is up around 140/90)
I have high BP normally, so little chance of controlling it w/ diet and exercise alone I just want to know what i'm taking is ok. I wasnt on anything w/ my other two kids.
Animal studies have revealed decreased embryo and neonatal survival in rats at doses up to 22 times (on a mg/m2 basis) the daily dose of 200 mg in a 60 kg patient, although there was no evidence of impaired fertility or teratogenicity. There are no controlled data in human pregnancy. Metoprolol should only be given during pregnancy when benefit outweighs risk. Metoprolol readily crosses the placenta. The maternal to fetal serum metoprolol concentration ratio is approximately 1:1. No teratogenic effects have been reported in human pregnancy. In a large study, the incidence of perinatal mortality was 2% of 57 hypertensive women who were treated with metoprolol alone, compared to 8% of 97 patients who were treated with hydralazine alone. No signs or symptoms of beta-blockade were noted in the fetuses or neonates. A case of a pregnant woman successfully treated with metoprolol for pheochromocytoma has been reported. Again, no signs or symptoms of beta-blockade were noted in the newborn. It is recommended that newborns who are exposed in utero to metoprolol should be carefully monitored for signs and symptoms of beta-blockade (bradycardia or hypotension) for at least 48 hours after birth. Incidentally, the plasma clearance (CL/F) of metoprolol is increased during pregnancy, averaging 362 mL/min/kg, compared to 82 mL/min/kg in the same patients postpartum.