A question for those of you out there supplementing with progresterone: I've had a few (4) miscarriages, and the recurrent miscarriage clinic told me I should start taking progesterone 72 hours after ovulation. I don't have a luteal phase defect, and my progesterone measures normal (but that was only one blood test, and I've read that you need a few tests to get an accurate picture).
Anyway, I am a bit leery about taking something for which there is no demonstrated need. Of course, that wouldn't be quite enough to stop me from taking it, given that you never know what might help with unexplained recurrent pregnancy loss. However, I am also worried about the safety of progesterone supplementation during pregnancy. Whenever I ask any of our docs about it, the response is always "well, your body naturally produces progesterone, so I wouldn't worry about it". Sure, but our bodies naturally produce estrogen too, and look what happened with DES.
Has anyone found any convincing information suggesting that progesterone is safe during pregnancy? Am I missing something here?
What did you end up doing? The only thing that I found was here that noted anything about studies related to the safety of progesterone supplementation in pregnancy.
"The conclusion reached upon extensive study of this topic at the Pope Paul VI Institute, specifically as it relates to the naturally-occurring hormone progesterone, is the following: There is no credible evidence to suggest that its use to support pregnancy, whether that support be in the early days or months of pregnancy or later in pregnancy, is, in any way, teratogenic or responsible for any genital malformations. In fact, all of the available evidence strongly supports it safety when used in pregnancy.
In this report, over 2,000 pregnancies were reviewed or reported with the use of progesterone support in pregnancy with no increase in birth defects or genital anomalies. Progesterone support in pregnancy can be considered completely safe!"
I was supplementing with progesterone during my first pregnancy, but that was because I was doing fertility treatments prior and needed the supplementation to support my cycles (for PCOS). I am now pregnant with a surprise 2nd pregnancy and they want to start supplementing just because I had it in the past. My level was within the normal range, but they would like to see it higher. At this point though, I'm not sure about the conception date which could be skewing the results. Anyway....needless to say, there seemed to be no issues with my first pregnancy and I've decided to supplement again with the 2nd because I'd feel terrible if I m/c just because I wanted to have a "natural" pregnancy for once.