I was diagnosed with PCOS this past December, and have been on a regimen of Sinthroid and Metformin since that time. The combination has worked beautifully, and I've had regular cycles (give or take the usual few days) since then. I'm a little worried though because I should have ovulated this past Monday, but I haven't yet! Admittedly, I was on a very hectic trip for the past two weeks (returned this past Sunday) and crossed several time-zones; I also slept horribly for those two weeks and had a myriad of other stressors as well during that time. Do you think that all of that could have thrown my cycle off? I'm just hoping that it's that and that it's not something worse (like the medication not working anymore). Any reassurances you can send my way would be very, very much appreciated!