I was canceled on my first IVF b/c of poor response to the long Lupron with BCP suppression protocol. I am 38 with FSH of 10.4 and AFC of 9, and have endo cyst on L-ovary. I am wondering if any other "older" women or borderline ovarian reserve/poor responders have tried the estrogen priming protocol and could give advice or tell their stories?
Thanks in advance.
Estrogen priming protocols: Older women (over 40 yrs), women who have demonstrated a prior reduced ovarian response to COH and those who by way of significantly raised cycle day 3 FSH and reduced Inhibin B levels are considered likely to be “poor responders”, are first given GnRH agonist for a number of days to effect pituitary down-regulation. Upon menstruation and confirmation by ultrasound blood estradiol measurement that adequate ovarian suppression has been achieved, the dosage of GnRH agonist is drastically lowered (or the agonist is replaced with a GnRH antagonist) and the woman is given twice-weekly injections of estradiol for a period of 7-10 days. COH is then initiated using a relatively high dosage of FSH-dominant gonadotropins such as Folistim or Gonal F that is continued along with daily administration of GnRH agonist/antagonist until the “hCG trigger”. A recently completed study has demonstrated the efficacy of this protocol and the ability to significantly improve ovarian response to gonadotropins in many of hitherto “resistant patients,http://forums.haveababy.com/lofivers...hp?t13024.html