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Old 05-21-2012, 04:56 PM - Thread Starter
 
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Hello Ladies -

 

I have a question for you all. I have suffered 3 losses in 20 months with no explained reason as to why. The fetal tissue was sent out and there was never a genetic abnormality. All of my losses have been at 8 weeks. I have 2 LC already. I was wondering if it is at all possible to have developed nka cells after my last pregnancy ? Any advice or stories that could be shared would be greatly appreciated.


Mom to a beautiful little girl ~age 4~ and adorable little boy ~age 3~ and wife to my main squeeze luxlove.gif
Two babes in heaven MC 6/23/10 at 8 weeks, MC 2/24/11 at 8 weeks, MC 3/2012 at 8 weeks ~ Praying for a rainbow1284.gif baby ~

 

 

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Old 05-24-2012, 03:26 PM
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Sorry you are dealing with this. I just tested for elevated NKA cells. I am going to SRAM though, and I am not sure if too many other REs do the testing. It was cheap and easy, so I would go for the testing if I were you. I have a 4yo DS, so obviously I didn't always have the elevated level.
 


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Moving past many years of infertility and always thinking of my friends in the infertility forums.

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Old 05-25-2012, 03:54 AM - Thread Starter
 
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RCR - thanks for responding . Did you get your results? Also i am sorry but what is SRAM?


Mom to a beautiful little girl ~age 4~ and adorable little boy ~age 3~ and wife to my main squeeze luxlove.gif
Two babes in heaven MC 6/23/10 at 8 weeks, MC 2/24/11 at 8 weeks, MC 3/2012 at 8 weeks ~ Praying for a rainbow1284.gif baby ~

 

 

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Old 05-25-2012, 06:20 AM
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Yes, I did get my results. It was 13.5. They like it to be around 9, so I am doing interlipid treatment for the NKA cells before my next IVF cycle. SRAM is Sher Institute for Reproductive Medicine. They have a big internet IVF practice, and are big into NKA cells. They do free telephone consultations, so you could set one up to discuss your concerns about NKA cells with them. : here is a link to their blog, discussing NKA

 

I'm not sure what they do about elevated NKA cells for those who are not doing IVF, but it is worth finding out.
 


Mom to DS 12/07 and DD 11/13, plus a bunch of chickens, dogs, and cats.

Moving past many years of infertility and always thinking of my friends in the infertility forums.

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Old 06-01-2012, 08:22 PM
 
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Natural Killer Cells are one possible cause of recurrent losses, but there are others you might want to consider as well.  There is a yahoo group for reproductive immunology that talks a lot about NKC plus more.

 

MTHFR mutations and immune/autoimmune issues are major causes of pregnancy losses.

 

I have had 2 recent losses - Dec 2011 and March/April 2012.  Both babies dated 6 weeks.  My Dec. miscarriage was 7 weeks.  My March/April was 13 weeks.

 

After my second loss, I've been diagnosed with (1)MTHFR homozygous C677T >>> treatment:  Lovenox with BFP and (2) recurrent immunologic abortion >>> treatment:  monthly IVIG and prednisone.

 

Many docs do not take MTHFR seriously and just say to take baby aspirin and folic.  My hematologist says that 6 week losses indicate they were caused by clotting from my MTHFR.  If you google Ben Lynch MTHFR, he has lots of up to date info re MTHFR and pregnancy.

 

Re the recurrent immunologic abortion (which is such a horrible dx name) - I have IgA deficiency plus vague immune/autoimmune issues thru the years.  With my first 2 children, I had over 50 serious episodes of mastitis.  With my 2nd pregnancy, pregnancy rhogam led to a +ANA a couple weeks later and a lupus dx (which lasted a few years and is no more).  With my 4th pregnancy/loss, rhogam with my miscarriage led to a +ANA but it went away a couple weeks later.  I have one other weird immune marker as well.   And I have likely developed anti-IgA antibodies in my 3rd pregnancy - my only child who does not have IgA deficiency.  With all of this, my immunologist actually got insurance approval for IVIG - which seems to be quite rare. 

 

Even with all of this going on, the hot shot university RE that my mw's backup doc sent me to said that none of this matters, since I have 3 children!  Just an example of the complete idiots out there that are supposedly helping women.  I have sought out my own specialists (hematologist and immunologist) and these are the guys who are truly helping me.

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Old 06-03-2012, 08:15 PM
 
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Sorry I just saw this post now.  Yes, you can develop active NK cells even after having children.  From what I have heard there is only a few places in the US that check for the right NK cells.  It is a NK 562 target cell test.  I had just the regular NK cells checked before I found out that it has to be specific test done at a specific place and the 1st blood test said my NK cells were fine, but then when I had the NK 562 one done it was positive.  Just an FYI.  Good luck to you!!! It is well worth it to find out, I'd say!!
 


After 5 failed IUI's & 6 failed IVF's we threw in the towel w/ ART and then got a NATURAL miracle BFP! Hoping and praying it is finally our take home baby!  Mother to our twins boys in heaven -lost at 22.5wks on 6/20/09 and 1 other little angel in heaven.

Our Miracle has arrived... Caden James...

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