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Some background: I am 41 years old and have experienced 7 miscarriages in the past 3 years. I did also have one successful pregnancy (yay!) in 2007, and I have three much older children. We would love to have just one more baby.
After three early miscarriages in 2006, I was diagnosed as compound heterozygous for the MTHFR genetic mutations C677T and A1298C.
I also carry the PAI (-675) 4g/5g genotype.
After this diagnosis, I was put on prometrium, Metanx (extra folic acid) and baby aspirin. Taking these meds, I was able to carry my next pregnancy to term. Since giving birth to my daughter in 2007, I have had several more early miscarriages.
I am now newly pregnant again (4 weeks and 2 days) and am taking the oral progesterone, Metanx and baby aspirin, but I am really wondering whether I should be more aggressive in treating my immune issue to try to sustain this pregnancy. My perinatologist told me I do not need lovenox or heparin, and he doesn't even want to see me for a regular office appt for 10 days, although they are having me come in for HCG/progesterone blood draws every few days.
I welcome any and all feedack on my situation. I feel very resigned to miscarrying yet again, and it's a very depressing place to find myself.
Typically hetero doesn't have any impact on increased blood clotting and homocystine levels, at least from the reading I've done. Did they check your homocystine levels and are they in normal range (did you get the actual number?)?
From what I've read compound heterozygous is a different situation (I am also compound hetero for MTHFR). Compound hetero means you have one of each of the genes instead of just one of them, and from my reading it is almost as bad as being homozygous for the C gene.
Jen, mama to (M-13, N- 10, C- 8
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