over 43 and pregnant, are you taking extra precautions? - Page 2 - Mothering Forums

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Old 07-08-2011, 06:43 PM
 
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 E.g., the risk of Down's syndrome is specifically related to the age of the mother. 

 

 

http://www.marchofdimes.com/birthdefects_downsyndrome.html

 

"Even though the risk is greater as the mother’s age increases, about 80 percent of babies with Down syndrome are born to women under age 35."


 

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Old 07-09-2011, 01:17 PM - Thread Starter
 
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Its interesting to me that the risk derives from the egg rather than the sperm. Even more interesting is the statistic you cited Serenbat. Nonetheless, I would be interested to know what  risks particular to older sperm is. I wonder if these sort of things have been studied

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Old 07-09-2011, 05:12 PM
 
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Quote:
Originally Posted by serenbat View Post

http://www.marchofdimes.com/birthdefects_downsyndrome.html

 

"Even though the risk is greater as the mother’s age increases, about 80 percent of babies with Down syndrome are born to women under age 35."


That is because the large majority of all babies are born to women under age 35.  A woman's personal risk for having a Down's baby is still most strongly related to her age.  (Additionally, since women over 35 are more routinely screened for Down's, they are more likely to have the option to terminate, which something like 90% of them will take IIRC.  Younger women are less likely to have the screening that would detect a Down's fetus, and so more of the Down's babies conceived by younger women will actually make it to term.)

 

Quote:
I would be interested to know what  risks particular to older sperm is.

 

Here is an article about the risks attached to older sperm (I found it on a fast google so don't vouch for its accuracy):

http://www.mothers35plus.co.uk/older-fathers.htm


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Old 07-10-2011, 08:44 AM - Thread Starter
 
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Thanks for the article Mambera.

 

It does say that down syndrome is also a risk from older men regardless of the womans age. Thats a suprising fact.

 

 
<<……..research published in November 2005, reveals that men aged 50 and above were more than four times more likely to have a child with Down syndrome……….>>>
 
 
 It also mentions that risk of miscarriage goes up for older men
 regardless of the womans age.
 
<<.....the risk of miscarriage appeared to rise along with the father's age, regardless of how old the mother was…
 
The risk of losing a baby was 60 per cent higher when the father was aged 40 or over, compared to when he was 25 to 29 years old. It was also about three times greater when the man was aged between 35 and 39 years of age, than if he were younger than 25…………>>
 
 
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Old 07-10-2011, 02:32 PM
 
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Congratulations on your pregnancy!!!  I understand why you would be worried.  As Sundaya pointed out - people who had a difficult time are more likely to want to connect on forums and share stories.  I just wanted to address a couple things you are worrying about that may have nothing to do with age.  First of all, the time it took you to conceive is more likely due to hormonal changes in your body and may be related to breastfeeding.  Although repressed fertility due to breastfeeding is less likely when baby starts solids and frequency of breastfeeding had slowed, it may still have effected your body's 'willingness to conceive.'  I personally doubt that your egg quality would change in a few years more than your hormones.  Just a thought.

Also, with regards to higher direct connections between maternal age, as far as strength  of the placenta, uterus, ovaries, is concerned, and reading that placental abruption can happen more easily because, well, its weaker in an older woman….I doubt it is age as much as health.  Many people in their forties experience (often unknowingly) a drop in HCL acid levels in the stomach.  This is why older people have a higher instance of acid reflux, and may be related to a harder time with growth and repair.  HCL acid is essential for digesting protein.  We are what we digest…not what we eat!  If a woman has low HCL acid levels and therefore isn't digesting protein effectively, it absolutely could lead to a weaker and less effective uterus and placenta.  It could also be related to the body's ability to make enough blood.  A woman's blood volume doubles during pregnancy, with the most dramatic increases happening toward the end of pregnancy.  This requires more protein and iron to build up blood supplies.  I've also seen in my nutrition research, increase instances of low levels of calcium and magnesium as we age, which are essential nutrients for building a baby.  But, all these changes are simply more likely in older people, and I would add, older people who don't take care of themselves and aren't in the best of health.  Poor habits due tend to catch up to you eventually.  (Also, its usually talked about in the over 50 crowd, instead of the over forty crowd)

Other things to be aware of are the health of the liver.  Liver health is absolutely essential in pregnancy, since a normal pregnancy does place extra strain on the liver (processing huge amounts of hormones.)  Let me quote an expert (and, I apologize this will be a long entry!)  

 

"Your liver performs 500 metabolic functions!  One of those functions is to purify and detoxify your blood. For example, during pregnancy your placenta produces high levels of female and pregnancy hormones; by the end of pregnancy, progesterone is a hundred times greater than the amount contained in birth control pills. During pregnancy, your liver must work at peak efficiency to regulate the level of hormones in the body by metabolizing and excreting extras. 

Think of your liver as a metabolic factory where nutrients from the food you eat are carried directly to the liver where they undergo changes and combinations so that they can be used by your body for new cell growth and repair, boosting your immune system, and giving you energy. One of the special proteins your liver synthesizes is albumin, which plays a critical role in blood volume expansion.

During the latter half of pregnancy, your blood volume must expand by 40-50% to send enough blood through the placenta to meet your growing baby’s needs and to store extra fluid in your body to prevent shock from blood loss during delivery. Your blood volume will not expand automatically just because you are pregnant; this change is dependent on an increased intake of protein and salt—and the production of albumin.

Albumin is synthesized in your liver by combining specific amino acids from the food you eat. Albumin acts like little sponges in your bloodstream drawing water from the tissues into the blood vessels.  Increased blood volume means increased perfusion of the placenta: your baby gets more oxygen, nutrients and hormones.

When a pregnant woman’s diet is protein deficient, her liver cannot produce enough albumin. When her albumin level is too low, fluid leaks out of her blood vessels into her tissues causing excess swelling and elevated blood pressure. Here’s why:

If the blood volume does not expand during the second half of pregnancy, the body will try to compensate in order to preserve circulation to all internal organs and the placenta by trying to increase the blood volume by re-absorbing sodium (salt) and water. However, if there is not enough albumin in the blood to absorb that extra water, it just leaks into the tissues and causes swelling, usually of the feet, and eventually of the hands and face.  

Salt to Taste to Maintain a Healthy Expanded Blood Volume

Every cell in your body, and your baby’s body, is bathed in salty fluid; your baby is bathed in salty amniotic water. You need extra salt in pregnancy to retain the extra water needed to expand your blood volume. Muscles depend on salt to function properly; leg cramps can be a sign of sodium deficiency.

How much salt do you need in pregnancy? The American College of Obstetrics and Gynecology recommends you salt your food-to taste (unless you have heart or kidney disease).  Don’t worry: you can’t ingest too much salt in pregnancy, anything extra will be excreted."  -Pam England

 

 I must admit I am a nutritionist and tend to see nutrition as the biggest factor related to health, even though I know its not the only one.  I recommend having a nutritional consultation, getting a diet analysis and seeing where you stand.  Pregnancy is a great time to make even an already healthy diet healthier.  Unfortunately many doctors and midwives don't have extensive education related to nutrition and may not look at diet much because they don't know what to do with it.  Don't let that lead you to believe nutrition isn't important, because it certainly it.  

There is always risks and unknowns when it comes to pregnancy and birth, but instead of being frozen by fear (so to speak), you can use it as a motivation to do what you can to increase health and wellness!  Good luck to you on your journey! 

Blessings,

Blair

 

 

 

 

 

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Old 07-10-2011, 05:49 PM
 
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Thanks for the article Mambera.

 

It does say that down syndrome is also a risk from older men regardless of the womans age. Thats a suprising fact.

 


So like I said, I didn't vouch for accuracy. ;)

 

You are right that I slightly oversimplified when I said there is *no* relation to paternal age, but I think the bottom line is the maternal age effect is far more important, and there is still ongoing debate about whether there is a small paternal age effect or not.  Some studies say yes, some studies say no.  It's difficult to do this work because you need a lot of data (fewer than 10% of DS children have a paternally derived extra chromosome) and there is a very strong statistical association of older fathers with older mothers, so a small effect of age in the father but not the mother is difficult to tease out.  Some studies found that the age of the father only becomes important given an older mother.

 

Here is a recent meta-analysis that found a small effect - it did not reach significance given the size of their dataset, which is kind of like saying they can't reliably say the effect was actually there - of paternal age.  It found a 13% increase in risk for each 10-year increment in the age of the father.  Compare that to a tenfold (1000%) increase in risk for a mother age 40 vs 30.

 

http://www.ncbi.nlm.nih.gov/pubmed/19449414


Me, DH, DD1 (5/2009) and DD2 (10/2011).
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Vaccines save lives.

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Old 07-11-2011, 09:24 AM - Thread Starter
 
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Thanks Blair. When you say older people are more likely to have acid reflux due to a drop in HCL levels, i feel reassured. Before pregnancy, i never experienced acid reflux, so  i hope thats a good indication that at least this much is working in my favor. (and perhaps others on this thread)

Mambera, thanks for the new link.

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Old 10-05-2012, 01:19 PM
 
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Ok im 43 and i was so happy i was pregnant then started spotting trying to get some medical attention incase to try to help save my pregnancy now i keep hearing of this progesterone now is this what i should of been given to help save the baby in my first trimester???????????? because i was so pregnant my stomach was forming unlike all my other miscarrages where my stomach was still flat and they were like a period now this time was so more emotional i had to wear maternity clothes my stomach was big now i had when to the ER and to seek help that i dont want to loose the baby where these idiot suppose to give me this progesterone could it of help save the baby because all they kept saying was that there was nothing they can do and one of the times this one idiot was checking the size of my uterus when i was in the doctors cuz i was spotting and high risk she was checking the size by almost felt like she was doing CPR on my uterus looking for size next few minutes the other idiot was doing a vaginal ultra sound i saw the freakn baby looked fine he said couldnt find heart beat 4 days later the baby came out at 8 weeks the baby died sometime but i looked 4 months pregnant and was showing so much did the lady press on my stomach and kill the baby was the baby already dead when i started to spot could it been i climbed mount fuji before i knew i was pregnant also could they of really help me save the baby by the way before the idiot pushed on my stomach my hgc level was at 22000 then after that it went 11000 on the day the idion pushen on me so maybe it was after mount fuji aug 21 she said the size of the baby was at 8 weeks when it demized so i guess my stomach kept growing thinking the baby was still alive my last period was july mid sometime so but i felt so connected with my growing stomach it was real emotional even more emotional then the last miscarrige 2010 when i almost bled to death but my stomach never formed yet i feel so jipped out of life so please tell me if they could of help save the baby with this medicine if so they are dumb as i went in circles trying to do something so i wouldnt loose it also how can i get pregnant again my husband didnt want the baby hes an ass but i did because it was there for a reason also since hes an asshole is it better that i lost the baby or should i try again? and if so how do i do it

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