|By the way, use of cytotec is contraindicated with VBAC (because of the increased risk of uterine rupture) and home birth (because of the need for continuous monitoring and the increased risk in general).
Um, actually use of Cytotec is contraindicated period
. There has been
an FDA warning on the drug, and even before that there was warning in the literature for the drug that says it should NOT be used to induce labor because of the large risk of uterine rupture. It's one of those drugs where you shouldn't take it if there is even the slightest chance you could be pregnant, because it is an abortifacient. In fact, it is used to induce abortion by some clinics.
However, OB/GYNs continue to believe it is safe:http://www.obgyn.net/english/ob/MisoprostolProtocol.htm
|I. Misoprostol (Cytotec) is a synthetic PGE1 analogue. It's FDA approved indication is for the prevention of stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs. Because of its prostaglantin activity it is also very useful for cervical ripening and induction of labor. Misoprostol has much the same mechanism of action, benefits, complications, indications, adverse reactions and contraindications as other cervical/vaginal prostaglandin products (e.g. Prostin¨ gel, Prepidil¨ , and Cervidil¨ ). Multiple studies have been done in multiple U.S., Canadian and European centers all showing the effectiveness and safety of Misoprostol for cervical ripening and induction of labor.
One would think they'd bother to read what Pfizer says about the drug. There is a large red box on the label of the drug which says: "Do not take if you are pregnant and do not become pregnant while taking this medicine because it can cause miscarriage or other serious complications."
The leaflet included with the medicine also states: "Cytotec can cause abortion (sometimes incomplete which could lead to dangerous bleeding and require hospitalization and surgery), premature birth, or birth defects...Cytotec has been reported to cause the uterus to rupture (tear) when given after the eighth week of pregnancy. Rupture (tearing) of the uterus can result in severe bleeding, hysterectomy, and/or maternal or fetal death."http://www.pfizer.com/pfizer/download/ppi_cytotec.pdf
From another info sheet on Pfizer's site:
|UTERINE RUPTURE HAS BEEN REPORTED WHEN CYTOTEC WAS ADMINISTERED IN PREGNANT WOMEN TO INDUCE LABOR OR TO INDUCE ABORTION BEYOND THE EIGHTH WEEK OF PREGNANCY (see also PRECAUTIONS and LABOR AND DELIVERY)
Now, I'll quote from labor & delivery:
|Vaginal administration of Cytotec, outside of its approved indication, has been used as a cervical ripening agent for the induction of labor and for the treatment of serious postpartum hemorrhage in the presence of uterine atony. A major adverse effect of the use of Cytotec is the hyperstimulation of the uterus which may progress to uterine tetany with marked impairment of uteroplacental bloodflow, uterine rupture (requiring surgical repair, hysterectomy, and/or salpingo-oophrectomy), or amniotic fluid embolism. Pelvic pain, retained placenta, severe genital bleeding, shock, fetal brachycardia, and fetal and maternal death have been reported.
(The emphasis above is mine.)
Please note that it says repeatedly
in many, many different sections of the drug's literature, that it should NOT be taken by pregnant women. And this was the case as well when I researched this while pregnant with my daughter back in 2000. So it's not as if it's new information for doctors to study.