I was told that I didn't have to wipe the cream off my nipples before feeding, but I tried to do that anyway because of the fact that there was polyethelene (sp) and mineral oil in the cream. Also, I personally felt the Nystatin was pretty worthless. If you are going to use it, though, take a look at the contents on the tube and see what else is in there besides Nystatin. I think a vinegar and water solution works well topically, for the nipples and for Baby's bottom, unless you or the Baby develop sensitivity to the vinegar. For me, I had a reaction to that stupid Nystatin cream.