what causes midline defects? - Page 3 - Mothering Forums

Forum Jump: 
Reply
 
Thread Tools
#61 of 89 Old 12-01-2009, 04:31 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
"These findings indicate the nutritional importance of vitamin B12, as well as folate, in the many clinical conditions where C677T-MTHFR is an etiological factor."

http://linkinghub.elsevier.com/retri...71531701003451


Pat

I have a blog.
WuWei is offline  
#62 of 89 Old 12-01-2009, 04:41 PM
 
quelindo's Avatar
 
Join Date: May 2005
Location: On the road to find out
Posts: 3,129
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by mombh View Post
Is a sacral dimple something your dr. or midwife would look for or point out to you? is it something you could miss if you are not looking for it??
Our midwife AND doctor both missed it. I just discovered it by accident when DS was several months old.

Formerly New Mama to Henry, born August 2005 and Silas, born November 2010.
quelindo is offline  
#63 of 89 Old 12-02-2009, 11:14 PM
 
Koalamom's Avatar
 
Join Date: Dec 2007
Location: Earth
Posts: 4,579
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
subbing to study later.
Koalamom is offline  
#64 of 89 Old 12-02-2009, 11:36 PM
 
FireWithin's Avatar
 
Join Date: Apr 2004
Location: Boston area
Posts: 3,340
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
I seem to need a lot of B12 to get results. Does anyone know if there is a connection between MTHFR gene and b12 absorption? When talking to Panser about it, and how when I greatly increased my sublingual B12, my iodine reactions disappeared, she seemed to think there was a connection. I want to understand why and see if there is something I can do it help improve it.

WHome posted earlier about low zinc reduces a body's ability to absorb folate - do you think it is the same with B12? I am low in zinc.

Children deserve the respect of puzzling it out.
FireWithin is offline  
#65 of 89 Old 12-03-2009, 12:28 AM - Thread Starter
 
Theloose's Avatar
 
Join Date: Aug 2005
Location: some planet
Posts: 6,478
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by Mammo2Sammo View Post
I seem to need a lot of B12 to get results. Does anyone know if there is a connection between MTHFR gene and b12 absorption? When talking to Panser about it, and how when I greatly increased my sublingual B12, my iodine reactions disappeared, she seemed to think there was a connection. I want to understand why and see if there is something I can do it help improve it.

WHome posted earlier about low zinc reduces a body's ability to absorb folate - do you think it is the same with B12? I am low in zinc.
If you're low in zinc and it's resulting in low stomach acid, then you won't be activating intrinsic factor well, and you need intrinsic factor to absorb b12 in the gut.

And you need b12 to absorb food folate.

But I don't know how MTHFR plays into absorption, unless it's a convoluted path of low/wrong folate->high toxins->low zinc->poor absorption of b12

allergy-nutrition mama, dh, 4yo dd, and March ds
Eating shouldn't be stressful!
Theloose is offline  
#66 of 89 Old 12-03-2009, 12:34 PM
 
KatWrangler's Avatar
 
Join Date: Mar 2005
Location: Affton, MO
Posts: 11,097
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Okay, I really need to set aside time to read this thread...

Anne, Mama to Conner 2/27/04 blahblah.gif  Gabrielle 2/6/06 W/LMC-TCS, Neurogenic Bladder, AFO & KAFO wearer, Neurogenic Bowel energy.gif & Delaney 5/12/08 mischievous.gif &  Beethoven cat.gif& Gizmo cat.gif

KatWrangler is offline  
#67 of 89 Old 12-04-2009, 10:46 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
More about the interconnection of B12 and folate and MTHFR (and mercury toxicity). http://www.ever.ch/medizinwissen/b12hg.php


Pat

I have a blog.
WuWei is offline  
#68 of 89 Old 12-05-2009, 04:20 PM
 
ASusan's Avatar
 
Join Date: Jun 2006
Location: Midwest
Posts: 4,913
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
I don't have the appropriate graduate degree to understand all the details in that link, Pat. But I read it, and I can understand the gist. Thanks! Happy that I took my B12 this morning, and wondering if perhaps I should keep an eye out for a good brand.

DS, 10/07. Allergies: peanut, egg, wheat. We've added dairy back in. And taken it back out again. It causes sandpaper skin with itchy patches and thrashing during sleep. Due w/ #2 late April, 2012.

ASusan is offline  
#69 of 89 Old 12-05-2009, 05:00 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
I just purchased some methyl B12 at EarthFare. Don't know about quality and brands. Also, consuming probiotics, cause they help B12 develop/grow/reproduce or whatever the intrinsic factor involved does, in the gut.


Pat

I have a blog.
WuWei is offline  
#70 of 89 Old 12-05-2009, 05:41 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Anyone have access to the full text of this study? (it was done in 1999, though) http://www3.interscience.wiley.com/j...00445/abstract


Thanks,

Pat

I have a blog.
WuWei is offline  
#71 of 89 Old 12-16-2009, 06:16 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
More B12 and MTHFR. Really important B12 info.


Pat

I have a blog.
WuWei is offline  
#72 of 89 Old 12-16-2009, 07:16 PM
 
deditus's Avatar
 
Join Date: Feb 2006
Location: In the LandOLakes missin the mitten
Posts: 2,986
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Jeez, I'll have to print it out and read it later. My menstruating brain is just not getting it on screen.

Emily, cooking allergen free, knitting, reading, gardening Mom to 1 beautiful girl, born in the water on July 1, 2006 Wife to 1 handsome man since September 10, 2005
deditus is offline  
#73 of 89 Old 12-17-2009, 12:20 AM
 
mombh's Avatar
 
Join Date: May 2003
Location: South Florida
Posts: 1,130
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
same here LOL
I just wasn't getting it.

But it got me thinking if there could be a connection with AVM. My 13 yr old dd has an AVM and long story short, it is not so common, but also something that there doesn't seem to be any info into causes besides the all familiar " one in 100.000.00 are born with it and we don't know why..."
btw, she never had a single symtom until now, she never even used to get headaches...

I have folinic acid, is that a better supplement?
mombh is offline  
#74 of 89 Old 12-17-2009, 10:44 AM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by mombh View Post
But it got me thinking if there could be a connection with AVM.
Per my quick review of Pubmed and ncbi, I do not see any correlation between AVM and MTHFR, or homocysteine, or folate, or B12.


Pat

I have a blog.
WuWei is offline  
#75 of 89 Old 12-17-2009, 11:36 AM
 
tanyalynn's Avatar
 
Join Date: Jun 2005
Location: TX, but anticipating one more move
Posts: 11,508
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 1 Post(s)
For the clueless among us what is AVM?
tanyalynn is offline  
#76 of 89 Old 12-17-2009, 12:59 PM
 
mombh's Avatar
 
Join Date: May 2003
Location: South Florida
Posts: 1,130
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
AVM - Arteriovenous malformation


From what I understand one or more blood vessels are malformed and as the person grows their is potential for compkications/symptoms like a "tangle" , bleeding etc;depending on where it is located etc;
most common is cranial, my dd has a small tangle deep in the thalamus, which suddenly out of the blue caused bleeding....
thank G-d she is o.k. but it is a scary thing and was so random in that we had no way of knowing....she is 13, has always been really healthy, doesn't get sick much, never had headaches, eats well, great skin, no cavities etc; thw only thing is gluten intolerence....go figure......
mombh is offline  
#77 of 89 Old 03-17-2010, 11:59 AM
 
Lady Lilya's Avatar
 
Join Date: Jan 2007
Location: Durham, NC
Posts: 3,721
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by New Mama View Post
Do you think if the father has a MTHFR mutation that could contribute to Down syndrome, or is it just the mother?

My DH's daughter from his first marriage (the third of his first three kids, born when he was 28 and his then-wife was 29) has DS. I know that *I* have a MTHFR mutation (and our son was born with a sacral dimple) but I couldn't get DH's doctor to test him for it. I know his ex-wife has a lot of low-level health issues & I wouldn't be surprised if she had a mutation, too, though.
If you look at my family, everyone on my father's side has the face structure associated with tongue tie. His mother, him, his brother, 3 of his 4 sisters, me, and my little sister.

My mother probably had low folate when pregnant. She was on birth control pills for a decade. She also probably had low vitamin D from working long hours indoors all year long. Good thing she always ate decently. Real foods, though not raw or organic or grass fed or unpasteurized etc.

So, what I figure is that the MTHFR variation comes from my father, and the nutritional conditions come from my mother.

Leigh, mama to Rostislav homeborn Aug 9 2007, and Oksana homeborn Feb 24 2011.
Lady Lilya is offline  
#78 of 89 Old 03-18-2010, 08:29 PM
 
brandislee's Avatar
 
Join Date: Feb 2010
Posts: 12
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Amazing information. Are stork bites/angel kisses (sorry, don't know the medical term- red blotches on the back of the neck or a v-shaped red patch on the forehead?) considered mid-line defects? My kids don't have sacral pits or any of the others, but both have these (and food allergies).
brandislee is offline  
#79 of 89 Old 03-18-2010, 09:21 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by brandislee View Post
Amazing information. Are stork bites/angel kisses (sorry, don't know the medical term- red blotches on the back of the neck or a v-shaped red patch on the forehead?) considered mid-line defects? My kids don't have sacral pits or any of the others, but both have these (and food allergies).
The medical term is Nevus flammeus. I've searched PubMed and can not find any studies relating a correllation between MTHFR and the Nevus flammeus. However, my whole family has the back of the neck red spot.


Pat

I have a blog.
WuWei is offline  
#80 of 89 Old 07-20-2010, 07:35 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Bumping!


Pat

I have a blog.
WuWei is offline  
#81 of 89 Old 07-21-2010, 04:05 PM
 
tanyalynn's Avatar
 
Join Date: Jun 2005
Location: TX, but anticipating one more move
Posts: 11,508
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 1 Post(s)
Quote:
Originally Posted by Mammo2Sammo View Post
I seem to need a lot of B12 to get results. Does anyone know if there is a connection between MTHFR gene and b12 absorption? When talking to Panser about it, and how when I greatly increased my sublingual B12, my iodine reactions disappeared, she seemed to think there was a connection. I want to understand why and see if there is something I can do it help improve it.

WHome posted earlier about low zinc reduces a body's ability to absorb folate - do you think it is the same with B12? I am low in zinc.
M2S, I just re-read this. You've read mamafish's discussion of one or a couple genes that increase a person's need for B12? Maybe that's involved?
tanyalynn is offline  
#82 of 89 Old 07-22-2010, 09:51 PM
 
JaneS's Avatar
 
Join Date: Jan 2003
Posts: 9,114
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by KatWrangler View Post
Okay, I really need to set aside time to read this thread...
Yeah me too, the recent mention of M2S's iodine reactions disappearing perked up my ears.
JaneS is offline  
#83 of 89 Old 07-23-2010, 11:16 AM
 
FireWithin's Avatar
 
Join Date: Apr 2004
Location: Boston area
Posts: 3,340
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by tanyalynn View Post
M2S, I just re-read this. You've read mamafish's discussion of one or a couple genes that increase a person's need for B12? Maybe that's involved?
Yeah I am thinking about that. Wish I could do the gene testing, but we are figuring it out on our own with all of you brilliant mamas help.

Children deserve the respect of puzzling it out.
FireWithin is offline  
#84 of 89 Old 07-23-2010, 11:18 AM
 
FireWithin's Avatar
 
Join Date: Apr 2004
Location: Boston area
Posts: 3,340
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
I started taking iodine again, with lots of B12 and my thyroid got huge. I could see it when looking in the mirror. I panicked a bit because I'm pregnant although I know this is the time the baby and I need it the most. I stopped taking it. I only took three drops of Lugol's spread out in a week. On paper I am majorly hyperthyroid, but I suspect it is my bodies attempt to search out the iodine I keep on giving it once in a while.

Children deserve the respect of puzzling it out.
FireWithin is offline  
#85 of 89 Old 07-23-2010, 11:30 AM
 
JaneS's Avatar
 
Join Date: Jan 2003
Posts: 9,114
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Antibodies testing?
JaneS is offline  
#86 of 89 Old 07-23-2010, 11:40 AM
 
FireWithin's Avatar
 
Join Date: Apr 2004
Location: Boston area
Posts: 3,340
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
Quote:
Originally Posted by JaneS View Post
Antibodies testing?
no not yet. So this would be testing me for hashi's (if I was hypothyroid??) what if my numbers are hyperthyroid? Is this info on the thyroid thread?
It is time to go into my family doc anyway and let her know I'm pregnant.

My family doc is against taking iodine

Children deserve the respect of puzzling it out.
FireWithin is offline  
#87 of 89 Old 07-23-2010, 04:13 PM
 
JaneS's Avatar
 
Join Date: Jan 2003
Posts: 9,114
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)
My understanding is with Hashi's you can bounce back and forth between hyper and hypo. Hashimoto’s Toxicosis is an autoimmune combination of Hashimoto's and Grave's.
http://emedicine.medscape.com/article/125648-overview
JaneS is offline  
#88 of 89 Old 11-04-2011, 04:09 PM
 
agirlnamedsuess's Avatar
 
Join Date: Nov 2010
Posts: 18
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)

I only definitely know the answer to your last question: it is the way the genes fall. My son, with Mosaic Down Syndrome, has a bifid uvula and also epispadias, both are midline defects; however, he has no cardiac anomalies or any other midline defect taht I am aware of.

As for the folate deficiency, it is probably true because doctors are seeing more *midline defects* with Down syndrome. Given that when you do the AFP test when pregnant to test for either Spina Bifida or Down Syndrome risk, either one, that would make a whole lot of sense.

As for the Vitamin A, I do know that there are strong links between autism and Down Syndrome, and often these conditions occur together as a dual diagnosis. That said, many parents of children with autism have found that their child is deficient in Vitamin A.

I hope that answers your question.

Susan

agirlnamedsuess is offline  
#89 of 89 Old 02-24-2012, 03:18 PM
 
WuWei's Avatar
 
Join Date: Oct 2005
Location: In the moment
Posts: 11,492
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 0 Post(s)

bump.


I have a blog.
WuWei is offline  
Reply

Quick Reply
Message:
Drag and Drop File Upload
Drag files here to attach!
Upload Progress: 0
Options

Register Now

In order to be able to post messages on the Mothering Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
If you do not want to register, fill this field only and the name will be used as user name for your post.
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



User Tag List

Thread Tools
Show Printable Version Show Printable Version
Email this Page Email this Page


Forum Jump: 

Posting Rules  
You may post new threads
You may post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off