Guess your genetics (Yasko related...) - Page 5 - Mothering Forums

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#121 of 307 Old 06-10-2010, 06:28 PM
 
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Got the enzymes today! So sprinkle on food slowly for DD right? She's only 2. Normal dose for me?
slow for you too!!!!!!!

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#122 of 307 Old 06-10-2010, 07:58 PM
 
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slow for you too!!!!!!!
Ok so slow for me would be 1 cap at each meal since directions say 2 with each meal? Sorry I didn't clarify this in my first post
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#123 of 307 Old 06-10-2010, 10:54 PM
 
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Ok I have another question. I have hashis so should I assume my methylation isn't working properly? I know my T cells are out of whack because I have Hashis and from what I understand methylation controls T cells...right????

I feel like I don't notice a difference on any supps I take and I'm just wasting money on all these supps so I hoping I will notice something with these enzymes. sigh
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#124 of 307 Old 06-11-2010, 12:23 AM - Thread Starter
 
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Ok so slow for me would be 1 cap at each meal since directions say 2 with each meal? Sorry I didn't clarify this in my first post
That would be fast ! Can't remember, do you have a nursling? If so, I'd open capsules and sprinkle them on food - like start with about 1/4 capsule a meal. If you don't have a nursling, then you can take it faster if you don't mind the possibility of feeling yuck for a few days.

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Ok I have another question. I have hashis so should I assume my methylation isn't working properly? I know my T cells are out of whack because I have Hashis and from what I understand methylation controls T cells...right????

I feel like I don't notice a difference on any supps I take and I'm just wasting money on all these supps so I hoping I will notice something with these enzymes. sigh
I don't know much at all about Hashis, but if you list some of your symptoms, and supps you've tried, I'm happy to try my amateur "guess your methylation needs" thing for you

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#125 of 307 Old 06-11-2010, 12:46 AM
 
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Ok so slow for me would be 1 cap at each meal since directions say 2 with each meal? Sorry I didn't clarify this in my first post
Which enzymes do you have? I started with 65mg 10x pancreatin per meal and got some major die off from that. I don't tend to be careful/play it safe with this stuff (I'm too impatient for progress ) so if I were being responsible, I'd definitely have gone significantly lower than that, even.

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#126 of 307 Old 06-11-2010, 04:52 PM
 
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Originally Posted by mamafish9 View Post
That would be fast ! Can't remember, do you have a nursling? If so, I'd open capsules and sprinkle them on food - like start with about 1/4 capsule a meal. If you don't have a nursling, then you can take it faster if you don't mind the possibility of feeling yuck for a few days.
I don't know much at all about Hashis, but if you list some of your symptoms, and supps you've tried, I'm happy to try my amateur "guess your methylation needs" thing for you
No nursling super slow sounds good to me then
Well Hashis is where you body is attacking your thyroid so I have this autoimmune thing going on which makes me think methylation. My thyroid is "stable" for now but I have fatigue and don't sleep well ever which I'm sure is adrenal related. I get migraines a couple times a month but other than that I just have little things going on and most recently have been very light headed.

I've been taking selenium, B-complex, mag glycinate, milk thistle, digest basic enzymes, vit D and methyl B12 and that's it


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Which enzymes do you have? I started with 65mg 10x pancreatin per meal and got some major die off from that. I don't tend to be careful/play it safe with this stuff (I'm too impatient for progress ) so if I were being responsible, I'd definitely have gone significantly lower than that, even.
I have the special digestive enzymes with pancreatin. Haha your funny....I really dont want any die off right now
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#127 of 307 Old 06-12-2010, 12:22 PM
 
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I spent the morning trying to translate yasko speak into 23andme speak. Fun stuff! I make no guarantees

MTRR
A66G is rs1801394; A is -
H595Y is rs10380; C is -
K350A (should be K350R?) is rs162036; A is -
R415T (should be R415C?) is rs2287780; C is -
S257T is rs2303080; T is -; not tested on 23andme

stay tuned for more

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#128 of 307 Old 06-12-2010, 05:33 PM
 
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K, here's the best I can do. A ? means I changed one of yasko's letters to make it work. The letter in parenthesis is what I *think* would be a '-' for Yasko. If there's a + after the letter, then that's what a + is in yasko speak. If the rs id is in parens, then I dont think 23andme tests it. Deb, did you have names for the nameless snps?
(don't know what's up with the *'s)

COMT * *V158M * rs4680 (G)
COMT * *H62H * *rs4633 (C)
COMT * *61 * * *rs769224 (G)
VDR * * Taq * *(rs731236) (T+)
VDR * * Fok * * rs10735810
MAO A * R297R * rs6323 (G)
ACAT * *1-02 * *(A+)
ACE * * Del16 * rs1799752 (I)
MTHFR * C677T * rs1801133 (C)
MTHFR * 3
MTHFR * A1298C *rs1801131 (A)
MTR * * A2756G *rs1805087 (A)
MTRR * *A66G * *rs1801394 (A)
MTRR * *H595Y * rs10380 (C)
MTRR * *K350A * rs162036? (A)
MTRR * *R415T * rs2287780? (C)
MTRR * *S257T *(rs2303080) (T)
MTRR * *11
BHMT * *1
BHMT * *2
BHMT * *4
BHMT * *8
AHCY * *1
AHCY * *2
AHCY * *19
CBS * * C699T * rs234706 (C)
CBS * * A360A *(rs1801181) (C)
SUOX * *S370S
SHMT * *C1420T (rs1979277)
NOS * * D298E * rs1799983

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#129 of 307 Old 06-12-2010, 06:28 PM
 
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Good work Whome, although I have NO CLUE what any of it means
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#130 of 307 Old 06-12-2010, 08:12 PM
 
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Originally Posted by mom61508 View Post
Good work Whome, although I have NO CLUE what any of it means
For anyone who gets a 23andme panel, it's super helpful. For everyone else, it's a bunch of random letters and numbers

Gonna go put my genetics in my ds thread...

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#131 of 307 Old 06-12-2010, 08:25 PM - Thread Starter
 
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Shannon, thanks so much for doing this. I asked 23andme to put me on a list so I would hear about their special sales - I want to test DD and DH too, but not at Yasko prices. So this is hugely helpful.

Anything I can add at the moment in bold below. I'll try to see if I can find any info on the nameless genes later.

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K, here's the best I can do. A ? means I changed one of yasko's letters to make it work. The letter in parenthesis is what I *think* would be a '-' for Yasko. If there's a + after the letter, then that's what a + is in yasko speak. If the rs id is in parens, then I dont think 23andme tests it. Deb, did you have names for the nameless snps?
(don't know what's up with the *'s)

COMT * *V158M * rs4680 (G)
COMT * *H62H * *rs4633 (C)
COMT * *61 * * *rs769224 (G) (confirm G is the -)
VDR * * Taq * *(rs731236) (T+)
VDR * * Fok * * rs10735810
MAO A * R297R * rs6323 (G) (DS' test, he's ++, says "T" here)
ACAT * *1-02 * *(A+)
ACE * * Del16 * rs1799752 (I)
MTHFR * C677T * rs1801133 (C) (confirm C is the -)
MTHFR * 3 (C is - here, and don't worry about it, really uncommon)
MTHFR * A1298C *rs1801131 (A) (yup)
MTR * * A2756G *rs1805087 (A) (yup)
MTRR * *A66G * *rs1801394 (A) (yup)
MTRR * *H595Y * rs10380 (C) (yup)
MTRR * *K350A * rs162036? (A) (yup)
MTRR * *R415T * rs2287780? (C) (Yasko's test results don't tell me the - if DS was hetero, unfortunately, so don't know for these next two)
MTRR * *S257T *(rs2303080) (T)
MTRR * *11 (G is -)
BHMT * *1
BHMT * *2 (C is -)
BHMT * *4
BHMT * *8 (T is the mutation)
AHCY * *1 (A is -)
AHCY * *2 (T is -)
AHCY * *19 (A is -)
CBS * * C699T * rs234706 (C) (yup)
CBS * * A360A *(rs1801181) (C) (T is mutation)
SUOX * *S370S
SHMT * *C1420T (rs1979277) (G is -)
NOS * * D298E * rs1799983

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#132 of 307 Old 06-12-2010, 08:35 PM
 
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Originally Posted by mamafish9 View Post
Shannon, thanks so much for doing this. I asked 23andme to put me on a list so I would hear about their special sales - I want to test DD and DH too, but not at Yasko prices. So this is hugely helpful.

Anything I can add at the moment in bold below. I'll try to see if I can find any info on the nameless genes later.
Awesome that your stuff matches so far

They have a list for sales!?

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#133 of 307 Old 06-12-2010, 09:36 PM
 
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bummer. genetic bypass isn't on google books anymore

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#134 of 307 Old 06-12-2010, 11:30 PM - Thread Starter
 
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I told them I am a member of a forum with lots of kids with food allergies, and I have a big group who would be really interested in learning about any discounts .

I posted on the Yasko forums to see if anyone can tell me more about the nameless SNPs. I also am browsing the data in the 23andme sample account.

Here are my guesses:

AHCY 2: rs1205357

I don't think 23andme tests the other two AHCY snps. However, the support for those is very similar to SHMT, which you do have identified.

BHMT: taking a leap that the 1, 2, 4, 8 refer to a sequence of mutations Dr. Amy was monitoring, guessing that:

BHMT 1: rs492842
BHMT 2: rs6894156
BHMT 4: rs6875201 or rs379754
BHMT 8: rs3797546 or rs567754

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#135 of 307 Old 06-13-2010, 08:50 AM
 
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this is seriously excellent work. y'all are gonna pull me back to mdc with this level of investigation!

Nessa, DD1 (5) DD2 (3) & expecting again in late February/early March!
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#136 of 307 Old 06-13-2010, 09:09 AM
 
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Wow, this all looks greek to me. will my test results come with any explanation?

Mom to DMI & Silly Apple
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#137 of 307 Old 06-13-2010, 10:58 AM
 
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Originally Posted by mamafish9 View Post
I told them I am a member of a forum with lots of kids with food allergies, and I have a big group who would be really interested in learning about any discounts .

I don't think 23andme tests the other two AHCY snps. However, the support for those is very similar to SHMT, which you do have identified.
Your resourcefulness never ceases to amaze me

The only thing is the SHMT I found isn't on 23andme... But if you read spittoon, the 23andme blog, they sometimes talk about id's that have been replaced by or are equivalent to other id's. I wonder if that's the case for the handful that aren't on 23andme, and how to even go about checking something like that.

Carren, I'm pretty sure the yasko results come with full explanation of what to do given your genetics. Don't worry.

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#138 of 307 Old 06-13-2010, 02:22 PM - Thread Starter
 
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Yeah, I saw the 23and me wasn't there, but that old blog post had it. Maybe something I will ask them - that one is something I want to know for DH & DD, it is one of two mutations other than the pancreatic ones that often results in bad guts.

I put DH on the gut bug killer supp (a bit of a stab in the dark for him), and yeeks. Bigtime die off, which for him means brutal migraines . So he has gut issues beyond what the digestive enzymes are tackling.

Carren, your results come with lots of nice explanatory help . What Shannon & I are trying to do is map the genes Yasko tests to the test she did (and which is sometimes offered at a discount that makes it a lot cheaper). So that someone doing that test could apply the Yasko thinking.

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#139 of 307 Old 06-13-2010, 02:32 PM
 
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We got the test kit in the mail.
I'm going to send it out tomorrow.

Normal is just a setting on your dryer.
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#140 of 307 Old 06-13-2010, 03:51 PM
 
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We got the test kit in the mail.
I'm going to send it out tomorrow.
How exciting!
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#141 of 307 Old 06-13-2010, 06:03 PM
 
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I'm sending mine tomorrow too. And I'll send in the detoxigenomics one on Wed. when I can get a blood draw.

Mom to DMI & Silly Apple
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#142 of 307 Old 06-15-2010, 09:12 PM
 
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Bump - not ready to have this get lost

Children deserve the respect of puzzling it out.
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#143 of 307 Old 06-16-2010, 10:58 AM
 
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I received 23andMe test results for me and DH today and am trying to figure it out. One specific question I have is regarding MTHFR. I previously tested heterozygous for both 1298A>C and 677C>T. Using the info from Shannon's post below, my 23andMe results show "AG" for 677T and "GT" for 1298C. Does this mean ++ for C677T and ++ for 1298C? DH's results are "GG" for 677T and "GT" for 1298C. It seems like it would make more sense if a G was "-". Am I not understanding this right?

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MTHFR * C677T * rs1801133 (C)
MTHFR * A1298C *rs1801131 (A)
Huge thanks to Shannon for figuring this out!
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#144 of 307 Old 06-16-2010, 11:21 AM
 
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I received 23andMe test results for me and DH today and am trying to figure it out. One specific question I have is regarding MTHFR. I previously tested heterozygous for both 1298A>C and 677C>T. Using the info from Shannon's post below, my 23andMe results show "AG" for 677T and "GT" for 1298C. Does this mean ++ for C677T and ++ for 1298C? DH's results are "GG" for 677T and "GT" for 1298C. It seems like it would make more sense if a G was "-". Am I not understanding this right?



Huge thanks to Shannon for figuring this out!
Hi!

The way 23andme shows data, is it gives you a letter for each of the alleles and it's up to you to figure out what that means. Sometimes it does it inverted though, just to confuse you. AG for C677T is inverted, so translate it to TC (T's and A's go together and G's and C's go together). Since you have one of each letter, that's heterozygous or +/- in yasko speak. Dh's GG is CC, so --. For A1298C, it's the same. Translate GT to CA, and you're both heterozygous or +/- for that one.

Seriously, I can't wait till this stuff is actually *accessible*!

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#145 of 307 Old 06-16-2010, 11:45 AM
 
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Wait, Shannon, does that mean you can be homozygous for BOTH MTHFR polymorphisms?

I'm confused about the choices... there are two locations along some gene where people have some variance, 1298 and 677... that's basically what those mean, right?

Are these the choices people have:
C677C (most common)
C677T (hetero...
T677T (is this possible? is this what it means to be homozygous?)

A1298C (this is hetero, right?)
what are our other choices here?
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#146 of 307 Old 06-16-2010, 12:40 PM
 
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Technically, yeah, you can be homozygous for both. But that seems really rare.

Notation-wise, C677T refers to the SNP. As in, it's usually a C at spot 677, but sometimes is a T instead. Everyone has 2 copies, so everyone gets two letters.

To show your own genetics, you'd do something more like C677T (CC) to show homozygous no 'mutation', or C677T (CT) (heterozygous), or C677T (TT) homozygous for the SNP. In yasko speak, CC is --; CT is +/-; TT is ++.

Then there's A1298C, which works the same way. But the two *are* connected, since they're part of the same gene. So the allele options are kind of like this:

------C---------A----- (fully functional)
------T---------A----- (this is C677T)
------C---------C----- (this is A1298C)

------T---------C----- (technically a possibility, but exceedingly rare)

So essentially, pick two of the first 3, and repeats are okay.

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#147 of 307 Old 06-16-2010, 01:13 PM - Thread Starter
 
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What Yasko does with her ++ stuff, is say - if CC is the most "normal" (NOT necessarily the most frequent, which is how many tests do it), I call that --. And she's only testing for SNPs where she knows the mutation causes issues (needs support) - so if you are +- or ++ for a gene, that means you need support. Makes it really easy to understand your Yasko genetics test, but a total pain to try to link it up to other tests. However, Yasko has done way more than anyone else I think in figuring out what to DO if you have most of these mutations, so it's worth trying to do the mapping.

Shannon, I have an email into the Yasko offices to get the call letter possibilities for each SNP, hopefully that will help us map the last ones. Question - how do you tell which ones 23andme inverts the call letters for?

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#148 of 307 Old 06-16-2010, 01:22 PM
 
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Originally Posted by mamafish9 View Post
Shannon, I have an email into the Yasko offices to get the call letter possibilities for each SNP, hopefully that will help us map the last ones. Question - how do you tell which ones 23andme inverts the call letters for?
Awesome!

On 23andme, when you're looking at a specific snp, there's a little + next to the gene name that you can click on for more info. That gives you links to look it up in google scholar or entrez gene or dbSNP. Next to that, it says "dbSNP Orientation:" and 'plus' (normal) or 'minus' (inverted).

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#149 of 307 Old 06-16-2010, 01:26 PM - Thread Starter
 
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Perfect, thanks Shannon! Waluso, if you post your genetics (the ones that map to Yasko), I can tell you which ones would be priorities/issues from a Yasko perspective.

Pick battles big enough to matter, small enough to win. ~Jonathan Kozel
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#150 of 307 Old 06-16-2010, 01:56 PM
 
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Originally Posted by mamafish9 View Post
Perfect, thanks Shannon! Waluso, if you post your genetics (the ones that map to Yasko), I can tell you which ones would be priorities/issues from a Yasko perspective.
Thank you! I posted the results for me/DH below. I would love your thoughts!

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Originally Posted by whoMe View Post
K, here's the best I can do. A ? means I changed one of yasko's letters to make it work. The letter in parenthesis is what I *think* would be a '-' for Yasko. If there's a + after the letter, then that's what a + is in yasko speak. If the rs id is in parens, then I dont think 23andme tests it. Deb, did you have names for the nameless snps?
(don't know what's up with the *'s)

COMT * *V158M * rs4680 (G) AA / AG
COMT * *H62H * *rs4633 (C) TT / CT
COMT * *61 * * *rs769224 (G) GG / GG
VDR * * Taq * *(rs731236) (T+)
VDR * * Fok * * rs10735810 AA / AG
MAO A * R297R * rs6323 (G) GG / T
ACAT * *1-02 * *(A+)
ACE * * Del16 * rs1799752 (I) DD / DI
MTHFR * C677T * rs1801133 (C) AG / GG
MTHFR * 3
MTHFR * A1298C *rs1801131 (A) GT / GT
MTR * * A2756G *rs1805087 (A) AA / AA
MTRR * *A66G * *rs1801394 (A) AG / AA
MTRR * *H595Y * rs10380 (C) CC / CC
MTRR * *K350A * rs162036? (A) AA / AA
MTRR * *R415T * rs2287780? (C) CC / CC
MTRR * *S257T *(rs2303080) (T)
MTRR * *11
BHMT * *1 rs492842? TT/CT
BHMT * *2 rs6894156? CT / CC
BHMT * *4 rs6875201 or rs379754? AG/AA or ?/? (i dont see this one)
BHMT * *8 rs6875201 or rs379754? CT/TT or CC/CC
AHCY * *1
AHCY * *2 rs1205357? TT/TT
AHCY * *19
CBS * * C699T * rs234706 (C) AG / AG
CBS * * A360A *(rs1801181) (C)
SUOX * *S370S
SHMT * *C1420T (rs1979277)
NOS * * D298E * rs1799983 GG / GG
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