When I was first married my dh was being medicated for ADHD. It didn't matter what med they gave him, he had little luck. Finally, I'd had enough and we went on an elimination diet. We started out with beans and started adding things as we became more confident that the beans were not the problem. Wheat was a trigger for both of us (migraines for me), as well as many preservatives, msg, food colorings, corn, peas, and some dairy. It makes it difficult to find food that can be tolerated, and completely eliminates Mexican food from the diet, but since we made the change he has mysteriously been cured of his ADHD. HMMMM.
Anyway, on the wheat thing, a friend of mine is reading a book by Sally Fallon (I'll have to think about the title) that describes ways to prepare grains to make them more digestable to humans and it helps make the nutrients more available. I have yet to read it myself but I would be interested in finding out what she says about wheat.