I've EFT'd monthly to Southern Poverty Law Center for the last ten years or so. I also give to the Blue Card Fund, which supports Holocaust survivors living in poverty, most of them under $12K/yr, most with no family. Among other things the Fund helps pay for dental care, holiday celebration, and crisis counseling and other psych support, which becomes more important as these people age, short term memory fades, and older memories resurface. I've just found out that there is a sister fund supporting impoverished Christians who risked their lives, and their families' lives, to save Jews during the Holocaust, and of course we must give to them too.
I do what I can to spread the word about the existence of these people and the charities -- I was shocked, and then ashamed, to find that these people who'd been through so much and been so brave & selfless should be forgotten and left to suffer in old age.
There's also an organization called The Parents' Circle -- it's made up of parents of Israelis and Palestinians killed in the various attacks and battles, and it strives for "peace, reconciliation, and tolerance". I give to them sometimes. We put money in a donation box every Friday evening and the recipients vary each time the box gets full.
I used to give to a bunch of other organizations -- ACLU, Amnesty Intl, the local PBS and NPR stations -- but have had to cull the list.
Goodwill, yes. I did used to look for places to leave baby/toddler items in good condition but it turns out the community is awash in these things and doesn't need any more.
Working on setting up a local Jewish Big Brothers Big Sisters. Not sure that counts, since it'd also benefit my family directly.
And of course I do what I can to help out other single mothers in the community, esp as they're going through divorce. At various times have given time & services to the local women's center, too.