Whenever I need to clean - whether that is to get down and dirty with major reorganization or to spruce the place up for guests or just to make my mood lighter and get dinner on the table - I start with a 15 minute Whirlwind...and anyone on the premises (anyone older than 3 that is!) participates. It is a fun race the clock pace and more than you think gets accomplished. For me, this semblance of blank space and order helps me think and get motivated. It also clears a staging area for all the piles that will form as I declutter!
Next, when I am tackling true deep cleaning, I start with the part I dread the most. This is usually my own closet or paperwork, for whatever reason. Once the dreaded chore is done, I can do the stuff that has less emotional baggage and actually feels good to clean. For example, I cherish the organization and cleaning of my son's room. I cherish each and every toy we have in his space because it was lovingly chosen to begin with. I also get teary sorting through the clothes he has outgrown as I remember all of the memories we created while he was wearing the clothes.
Finally, I tackle each area by making several piles. (Have trash bags and donation bags ready!) I either 1) toss or recycle (ancient, ratty bras or torn socks, panties with the elastic gone, etc...) 2) donate (toys that were gifts we don't want son to have, duplicates of things, things I haven't used in a year) 3) refold, file or organize (good clothing, important papers or spices in the cabinet). Personally I get rid of as MUCH as possible every time I clean. With time, the piles do get smaller!
Cleaning in preparation for a new baby is always a sacred event for me. Usually I put on good music, light incense and hold the intention that I am preparing the way to welcome a new family member - the way I would prepare for an honored guest. This takes away the resentment and overwhelm I might otherwise feel when faced with all the shit we accumulate in life.