In a word, yes. Since DS's was about 20, 21 months, we have days where naps just don't happen in the usual routine--we try but it just isn't happening. I have a few mommy guidelines I follow when this happens...
First, if he's not down by 2:30-3ish, I tend to discourage the nap at all. He's an UP ALL NIGHT guy if he takes a late nap. This is one of the few things that really drives me bonkers. Nighttime is my only downtime and I need it.
Second, once I realize that the nap isn't going to happen, I tend to keep activities light and less stimulating than usual for the remainder of the day. In addition, I feed him something hearty in the late afternoon because once he's tired, dinner can be iffy.
Third, I put him to bed early. Even as early as 6:30 if necessary... if he's in good spirits, I keep him up as long as he stays even keel, 7:30 is usually the latest he'll want to stay up if he hasn't napped. When things start getting rough around the edges, we do an abbreviated bedtime routine and off to slumber we go. He out in seconds and usually sleeps right on through to the usual wake up time.
If this only happens once a week, great. But I always try to help him back to his nap routine the very next day because honestly, he does better with the nap. If he goes two days in a row without one, there seems to be this cumulative effect on his sleep and it really changes his pesonality. KWIM?
Best of luck!