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Generally, we now start domperidone at 30 mg (three 10 mg tablets) 3 times a day. In some situations we go as high as 40 mg 4 times a day. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance. You can take the domperidone about every 8 hours, when it is convenient (there is no need to wake up to keep to an 8 hour schedule—it does not make any difference). Most mothers take the domperidone for 3 to 8 weeks, but sometimes it is needed longer than that, and sometimes it is impossible for mothers to maintain their milk supply without staying on domperidone. Mothers who are nursing adopted babies may have to take the drug much longer. People taking domperidone for stomach disorders are often taking it for many years.
After starting domperidone, it may take three or four days before you notice any effect, though sometimes mothers notice an effect within 24 hours. It appears to take two to three weeks to get a maximum effect, but some mothers have noted effects only after 4 or more weeks. It is reasonable to give domperidone a trial of at least four, and better, six weeks before saying it doesn’t work.
For more information on how to wean off the domperidone see the handout: Domperidone 2.
Originally Posted by jenny-g
There are side effects to domperidone, like any drug. It prolongs the QT interval of your heart, basically meaning if you have a heart issue, you should be very careful taking this drug.
Most importantly, taking this with ANOTHER drug that prolongs the interval can be risky. Some of these drugs are common for bf moms to take- like diflucan and some antibiotics.
A study by Heykants (1) has shown that absorption of domperidone increases from 13% to 23% if domperidone is given ninety (90) minutes after eating. This means that the drug will act most effectively when mothers take it an hour and a half after eating.
|A US Federal Judge ruled that compounding pharmacies in the US can make any drug they wish and cannot be restricted by the FDA (Federal Drug Adminstration) -- that the FDA has no jurisdiction over them. This is fantastic news for being able to get domperidone in the US. This means all those drastic warnings from the FDA to compounding pharmacies threatening legal action if they made domperidone are now negated. Any US physician can prescribe domperidone and any US compounding pharmacy can make it LEGALLY.
A very big day for domperidone. Please spread the news.
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