Denmark study associates DTP with increased mortality - Mothering Forums

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#1 of 8 Old 05-26-2012, 08:52 AM - Thread Starter
 
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So why have we not heard any mention of this?

 

http://www.ncbi.nlm.nih.gov/pubmed/22239846

 

"The inactivated DTP vaccine worryingly has been associated with increased mortality from other infectious diseases. Both positive and negative effects are strongest for girls."

 

Please read the whole abstract, as there are several interesting findings presented.

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#2 of 8 Old 05-26-2012, 09:50 AM
 
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So the study is actually about the effect of giving high dose vitamin a supplements with vaccines. The thing on mortality is tossed in as a known fact. I wonder what study it came from and if it applies only to the developing world? It could be as simple as because fewer children die from d, t, or p more die from something else, because they live long enough to be exposed to it. Also curious about the overall mortality rate, is it lower overall and just higher for certain things or is it higher overall?

Off to try and track down the original study . . .
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#3 of 8 Old 05-26-2012, 09:55 AM
 
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Haven't tracked down the full text yet, but to looks promising

http://www.ncbi.nlm.nih.gov/pubmed/20431383
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#4 of 8 Old 05-26-2012, 10:05 AM - Thread Starter
 
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Rrrrachael, those are really good questions.

 

I think it's great to investigate ways to prevent death from illnesses, but there are so many confounding factors, incorrect assumptions, and limitations in the way these studies were done. And it really bothers me that deaths of female children were written off in 1995 as being unrelated to the vaccine, when now we know that there ARE factors that affect response to both vaccine and illness by gender.

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#5 of 8 Old 05-26-2012, 10:08 AM
 
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Dang it, I can't get the full text of this one, either, but it looks interesting (you would like it, Taxi) and the list of articles citing it look good, too. I'm going to those next.

http://adc.bmj.com/content/95/9/662

I am between institutional logins at the moment, maybe someone who does have one can hook us up with some summaries or something.
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#6 of 8 Old 05-26-2012, 10:15 AM
 
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http://bmjopen.bmj.com/content/2/3/e000707.full

Most of these seem to be dealing with high mortality countries. I haven't found anything to say whether or not the results apply to somewhere like the us.
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#7 of 8 Old 05-26-2012, 10:16 AM
 
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#8 of 8 Old 05-26-2012, 10:28 AM
 
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WHO has an interesting response to the original article.

http://www.who.int/bulletin/volumes/81/11/cooper1103.pdf

"In the study from Benin West Africa (18), although the estimated increase in mortality following one dose of DTP and one dose of oral poliovirus vaccine (OPV) was elevated compared with unvaccinated children (relative risk = 2.2), this increase was not statistically significant. The risk estimate decreased with increasing numbers of DTP doses from 2.2 at one dose of DTP to 0.7 at four doses. With respect to BCG vaccine, the estimate for mortality reduction in vaccinated vs unvaccinated children was 0.38."

Lots more good stuff here. Glad this study isn't just being ignored!
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