I'm going through the same thing. My BIL, who's a urologist, said he didn't think the estrogen cream would help as much as the actual application of the cream. It's the rubbing it in that's breaking down the membrane. He recommended using Neosporin or similar ointment. Unlike the PP, who said they had the membrane gone in 3 weeks using small amounts of estrogen cream, our DDs has not gone away. (We've been switching between using KY Jelly and the neosporin.) This makes me think the estrogen cream must have some benefit. I'm starting to get uncomfortable waiting for it to clear on its own. I really don't want it to become worse, so for us I'm thinking a small amount of estrogen may be worth it. I also read that once it clears to keep applying something like KY Jelly each night so the skin cannot re-adhere.