Join Date: Aug 2002
Location: Down by the River...
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Any stress to your immune system can cause an outbreak. That's why they are called "cold sores"--it's common to have an outbreak as you're coming down with a cold or other bug, as your immune system is taxed fighting off the invading germs. So similarly physical or emotional stress, sleep deprivation, and anything else that takes a toll on your body can bring it on. HIV is definitely one of those, but definitely not the most likely if you have regularly tested negative!
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