Clinical Chemistry, Vol. 41, No. 8, 1995, 1094-1104
Increased Urinary Excretion of Analogs of Krebs Cycle Metabolites and Arabinose in Two Brothers with Autistic Features
I hope someone can enhance my understanding of this study. According to this research article autistic children have elevated levels of metabolites such as citramalic, tartaric, and 3-oxoglutaric acids (as well as arabinose). The children who participated in the study appear to have elevated levels of unknown metabolites as well. The study makes reference to the potential discovery of an unknown citric acid found in high levels in autistic children.
I have a ton of questions but I will start with this quote.
|Citramalic acid (2-methylmalic acid) and 3-methylmalic acid are analogs of the Krebs cycle intermediate malic acid and might interfere in the further metabolism of malic acid, leading to depletion of oxalacetic acid, the product of the action of malate dehydrogenase on malic acid. Oxalacetic acid is needed for condensation with acetic acid to replenish the Krebs cycle. A significant decrease in Krebs cycle activity could greatly impair cellular energy production. ......Citramalic acid has not been reported as a mammalian metabolite but has been reported to accumulate in respiration-deficient mutants of brewer's, baker's, and wine yeasts. Furthermore, an enzyme that catalyzes the condensation of acetyl coenzyme A(CoA) and pyruvate to form citramalic acid has been isolated from baker's yeast. In addition, we have found citramalic to be consistently produced by Propionibacterium acnes cultures from human stool samples (unpublished data).
The first thing I did after reading this study was to do a search on these varioius acids. Fortunately, I found a page on this site that describes these and other types of acids. www.greatplainslaboratory.com/test1comp2.html
What exactly is the Krebs cyle and how does impairment of its process relate to autism?
In terms that a lay person can understand, what is metabolism?
And considering the description of the various acids mentioned in the study is there a possible connection between the vax ingredients and the elevated level of these acids in autistic children?
I also found it interesting that the children in the study were treated frequently with antibiotics in infancy for ear infections....and we know what antibiotics do to healthy gut flora.
Basically, I am looking for someone to break this information down in relation to vaccines and autism. I don't recall the study saying whether or not the children were vax but assuming they were, I wonder if the study unwittingly establishes a link.