A number of ingredients in over-the-counter treatments may help your skin appear more youthful.If you have fine lines, retinoids (which come from vitamin A) like retinol may make your skin smoother because they help your skin make more collagen.Treatments with topical growth factors or peptides could help firm sagging skin. Peptides are groups of amino acids that help make proteins, including collagen. That's the main protein found in your skin. Hydroquinone, an over-the-counter drug that can bleach your skin, may fade dark spots. Retinoids may make your skin tone more even. One study says vitamin C helps fade age spots when you use it for 12 weeks. Kojic acid -- a chemical that's often used as an skin-whitening ingredient in products -- can do it, too.