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-   -   Elevated beta-glucuronidase in 9-year-old (

mommyabroad 11-01-2012 11:51 AM

DS's Comprehensive Digestive Stool Analysis indicated nothing out of range except for very, very elevated beta-glucuronidase?  Over 16,000.  What does this mean and how can we treat it?  And what causes this?


DS is 9.


There is a history of digestive issues- - your guidance is greatly appreciated.  We did just discover an egg allergy.  This is new information to us.


Thank you!

Dr Neustaedter 01-16-2013 02:30 PM

Here is an answer from the Genova website that does these types of stool analysis. In general an elevated level of this enzyme is more predictive of problems than diagnostic of anything in particular.


The following interventions may help to reduce beta-glucuronidase levels:
Probiotics (including Lactobacillus acidophilus,13 Lactobacillus GG,14 and
High-fiber diet (including both soluble and insoluble fiber)16,17,18
Fructooligosaccharides (FOS). FOS may act as a substrate for bifidobacteria.
Combining FOS with cellulose may be even more effective.19
Low- or non-meat diet.20 Lacto-vegetarian diets are associated with reduced levels
of beta-glucuronidase.21
Lowering colonic pH. Raising fecal pH from 5 to 8 in vitro induces 11.5-fold rises in
beta-glucuronidase levels.22
Calcium-D-glucarate inhibits the enzyme.23,24 Foods with the highest concentration of
calcium-D-glucarate include oranges, apples, grapefruit, and cruciferous vegetables.25
Ascorbic acid26
Silymarin (milk thistle)27
Cumin or black pepper (avoid cayenne, which can increase levels of the enzyme)28

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