[TrishWSU]

I just read through the FAQ: Domperidone thread but didn't find what I'm looking for, so I figured I'd ask here.

My IM (intended mom-I'm a surrogate) is in the process of inducing lactation following the protocal on www.asklenore.com but as she was researching the Domperidone she found out it interacts w/ another medication she currently takes. The medication is safe for breastfeeding, but the Domperidone and the medication together won't work. She's really hoping to be able to exclusively BF the baby, but will have my milk if she needs it. So, with that being said:

1. Is there a safe alternative to Domperidone (prescription or herbal?)

2. Is the Domperidone absolutely necessary for inducing lacation? Will not taking it affect how much she is able to produce if she doesn't take it? (she has never carried a pregnancy past the 1st tri and she has severe PCOS)

TIA for any help you can provide. I am only 7 weeks along so she has a lot of time to get ready, but we're hoping for the best results-a full supply!

 

[RootSnort]

I am a hospital pharmacist and have a great database available to me. What medication is she taking so I can check and see if it's a real interaction?

Other options for inducing lactation include:
Pumping a lot
Fenugreek capsules, 3 capsules three times daily
Reglan 10mg 4 times daily

Good luck and keep us posted!

 

[CathMac]

Trish,
I am a Working and Pumping Mom. I struggled with a number of issues, including supply, with DD1 (not that I'm complaining, I could have had it much worse).

I did a lot of research on galactagogues, especially when I experienced a sharp supply drop when I was pregnant with DD2. The thing that seemed to have the most dramatic effect was a regimen of Inositol and Choline that I sort of figured out on my own as an alternative to the better known galactagogues. It's not usually the first thing I recommend since it seemed to make me dizzy. However, I'm guessing you are familiar with all of the other options.

I should note that it wasn't a "scary" kind of dizzy, but then again it never seemed to happen when I was driving; which may have to do with when I took it during the day. Also, the dizziness went away very shortly after I discontinued the regimen, within a matter of days.

If she were to decide to an Inositol and Choline regimen I would suggest starting with half of whatever the bottles give as a recommended minimum dose.

I periodically post and re-post my standard spiel on Working and Pumping (Supply/Galactagogues and Pumping tips, etc.). You could probably find them fairly easily by doing an advanced search using my member ID "Cathmac" and the appropriate search terms. I think the pumping tips could be helpful in trying to give her supply an additional boost.

I'd simply re-post them here but I'm guessing the "regulars" get tired of seeing me rehash the same thing over and over again. If I seem like a broken record on occasion it is for the rather obvious reason that my heart goes out to women that struggle with these issues.

If you can't find my previous posts feel free to PM me.

~Cath

PS - If you are curious, my research led me to Inositol and Choline (I&C) as the "active ingredient/component" (for lack of a better term) in a number of well known galactagogues, including Oatmeal and Brewer's yeast. They are in the "B vitamin" family. As best I can figure, in layman's terms, Inositol and Choline do not increase the milk producing hormone (Oxytocin if I remember correctly) but does somehow enhances its "uptake" &/or its effectiveness.

 

[TrishWSU]

Quote:

Originally Posted by RootSnort I am a hospital pharmacist and have a great database available to me. What medication is she taking so I can check and see if it's a real interaction?

Ok, here is what she sent to me in an email:

Quote:

I am taking Glumetza. It's a new drug, and is a different formulation of Metformin. Metformin is usually broken down in the intestines, and I can't take it because of horrible side effects. Glumetza is broken down in the stomach, and it is extended release, so one dose takes 24 hours to break down. The problem with the Domperidone is that it empties the stomach quickly, and would essentially empty out all the meds too quickly. That's what I have read, and I don't know if it's true, if it's a real problem, or if there's a way around it.

So is this truly a prblem with the two or is it one of those slight possibility thing?

Ya'll have been so helpful so far. I'm off to check the Inositol and Choline thing out. Thanks!

 

[RootSnort]

I ws unable to check interactions using the MIcroMedex program at qork - they don't file information on either of these drugs yet.
However, I checked the prescribing information for glumetza, and there is no interaction with Reglan, which is also a pro-kinetic agent. So, my suspicion is that we would be OK. But I suspect that no one has any for-sure data.
http://www.glumetzaxr.com/pdf/current_PI_PW2.pdf

 

[Iigi]

Sorry for bump. I started on Reglan and had great results and have since switched to Domperidone. I did get more milk on dom. With that said I preferred the lower risk of side effect with the domperidone.