When I was pregnant with my DD, I took Compazine, but had bad reactions to it and just ended up suffering until my 7th month. This time, I've got Zofran. It's stronger, and hideously expensive, but it's the only thing that has made me vaguely functional. I'm still puking a couple times a day, but the unending nausea has let up enough to let me at least pay attention to DD.