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Discussion Starter · #1 ·
After three MCs, my doc sent me to an endocrinologist with a diagnosis of recurrent pregnancy loss. The endocrin did genetic testing and found that I have a predisposition for thick blood. I have no issue getting PG, and have even seen a heartbeat, but it's staying PG that's the issue.<br><br>
So, bright and early tomorrow morning I get to start shooting up with Heparin twice per day. Anyone have experience with it?
 

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I'm on Lovenox due to a blood clot at 10 weeks in my last pg. Was on it til 6 weeks pp, then back on it about 2 months later when i found out I was pg again. My first does (treating the clot) was 2xs a day. Now, just as a precaution I only take it once.<br>
I'm certainly not a doctor, but I assume you are on Heparin to thin your blood til you get pg, then will probably move to Lovenox to keep it thinned during at least the first trimester.<br>
The shots are annoying and sometimes hurt (as many as I've given myself, I still can't determine how to do it so it doesn't hurt...it's random wether or not it will hurt or bleed) but you do get used to it and it just is what you do.<br>
Let me know if I can help any...
 

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I have been on Heparin 5000u every 12 hours since 13 dpo with this pregnancy. After my third miscarriage, I had RPL testing and have MTHFR and protein s deficiency. I will stay on it until term, then discontinue for the birth.<br><br>
I inject in my abdomen twice a day. My midwife draws blood to check platelets and PTT. Some shots I don't notice at all, some burn a little. The bruising comes and goes too. It is just a normal part of my routine now. No big deal, really.<br><br>
I wish you a healthy, normal pregnancy! Best wishes to you!<br><br>
Amy
 

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I did Heparin in one pregnancy. I had dual dose ampules that I drew up the doses out of, which was the biggest pain of the process. All my injection sites bruised pretty badly. I had a couple spots that bled a tiny bit. I used a 1cc insulin needle, swabbed with alcohol and pinched the site while I injected, then released the skin as I pushed the plunger in.<br><br>
Good luck!
 

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Sorry to butt in here, but since you ladies have some experience with blood clotting disorders, I was hoping you could answer a question for me.<br><br>
Are there any symptoms of a clotting disorder other than recurring miscarriages? I have had two miscarriages in a row and I was trying to decide if I should get the clotting test done.<br><br>
Thanks!
 

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There can be symptoms other than losses, but usually only for severe clotting problems. For example, I have antiphospholipid antibody syndrome... an autoimmune thing. Guys can have it, young kids can have it, it's definitely not just pregnancy-related. One form of the disease is called "catastrophic APA" where the bod just starts throwing off clots all over the place, causing one organ after another to fail. People usually die within a week, even in a hospital. Freaked me out when I first was diagnosed. Obviously, I don't have that kind, and almost no one does. It's extremely rare. The MTHFR gene variations do go along with nutritional issues... I know over in Health and Healing at least one gal has accidentally discovered she has that, even though she's never had a clot (and maybe never a loss). But now she knows she needs more B vitamins and zinc (or something like that). So, I suppose, her stubborn deficiencies of B and zinc were a non-clot sign of MTHFR, but most people would totally miss it.<br>
I have teeny red spots on my skin that I've read have a fancy name and might be an outward sign of a clotting disorder. My headaches in high school, while on the Pill, may also have been a sign, but no one has scanned my head to see if I've had past mini-strokes.<br><br>
So, yeah... there are other signs, but they are somewhat vague and can easily be due to other things.<br><br>
As for heparin injections... I'm now 33 weeks along and have been "shooting up" since 4 1/2 weeks. Same as sew_crafty_girl, I had to carefully measure from the little multi-use bottles. I use insulin needles (although they tried REALLY hard to have me use tuberculin needles, which ended up being too hard to find, but insulin needles are MUCH better.) They instructed me to pinch an area, clean it with an alcohol pad, and then punch the needle in... just jab it real fast. I have NOT found that to be the best way. I poke around the cleaned area gently, finding a spot that doesn't hurt as much. No idea why some spots aren't as sensitive, but I learned early on that just punching away ended up with me injecting that burny heparin into some extremely sensitive places. The poking hurts a little, but nothing compared to forcing it into a spot that said "no." I have tons of stretch marks from my first pregnancy, and have found that those are often perfect areas for injections. Thinner skin, fewer nerves.<br><br>
The shots suck, the bruises suck, but hopefully it'll all be worth it.<br><br>
Oh, and in my case they started me at 5000 units, twice per day. Once I hit the second trimester, they bumped me up to 7500 units, twice per day. Now, in the third trimester I'm at 10,000 units, twice per day. I've just been told that there are new guidelines on heparin... that perhaps because of dosing problems they are going to be diluting it, which will make us have to take it 3 times a day. I have my appointment tomorrow to officially find out what's up.
 

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I have MTHFR and I took Lovenox for 25 weeks in my 3rd pregnancy.<br>
With my 2nd loss, I was not taking anything yet and I had that loss at 16 weeks.<br><br>
With my last pregnancy (8th pg, 4th live child), I took baby aspirin before I got pg, and I also took 4 mg of folic acid and drank grape juice every day.<br><br>
Good luck to you!<br><br>
Taking lovenox was not terrible, but I had to give myself the injections 2x a day in my belly from 10 week till 35 weeks.<br><br>
Take care,<br><br>
Jen
 

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Discussion Starter · #8 ·
I started this when I was freaking out one morning, then never came back... Thanks ladies for all your responses.<br><br>
I've been on 5000 2x per day with a .5cc insulin syringe. I am highly allergic to latex, so I have to have special needles and special latex free bottles to pull the doses out of.<br><br>
I'm coming up on 12 weeks this coming Thursday. Have had ultrasounds and blood monitoring every other week since 5 weeks. Endocrin wants me on the heparin until 16 weeks. I'm not too happy about coming off it early (in fact, quite terrified about it), but he believes once the placenta is well developed the fetus risk of stroke from the uterus will be nearly gone in my case.<br><br>
As for bruises--expect them! I rarely bruised my entire life--and I played soccer all the way through college. I would get hit, then it would kind of feel like a bruise, but there would never be any discoloration (apparently, thanks to the thick blood I've got). So that could be a sign outside of genetic testing. According to my doc, based on my answers to his questions about the following things, is also what led him to order the genetic testing:<br><br>
- My extremities are often cold<br>
- I have extremely low blood pressure (when I'm severely stressed, I'll come in somewhere around 110 over 70)<br>
- I'm a redhead (apparently it's a common go-with for the sensitivities and allergies that come with being fair skinned)<br><br>
As for the shots, sometimes they hurt, sometimes they don't. They usually hurt most just as I'm finishing the push on the plunger. My instructions differred slightly, as I was told never to pinch the skin with Heparin. Start icing 5-10 minutes in advance, fill the needle with air, inject air in the bottle, then draw up the dose. Swab the area with alcohol, let the alcohol dry for a few seconds, then pull skin taught and stick it in. Push in the plunger while still holding taught, then pull straight back out. Replace ice for another 10 minutes or so. The injection sites often bleed, and sometimes it appears that some of the heparin oozes back out the needle hole (clear fluid instead of blood; or mix of two).<br><br>
As for the bruises, they seem to come and go in waves, but my entire abdomen feels like one giant bruise all the time (loading the dishwasher is hell). When I get them, they are about three inches in one direction and four in the other, and they are quite spectacular. The more I take the heparin, the bigger they seem to get. It must be doing its job by preventing clotting, so this is a good sign in my opinion.<br><br>
But in the end, I've decided, I love the pain. The pain of each bruise means I'm that much closer to finally holding my own tiny little being... <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/winky.gif" style="border:0px solid;" title="Wink">
 

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Good news, momma! I'm so happy you are doing well. Bruised, but good! If you are not comfortable stopping at 16 weeks, talk to your doctor about the risks/benefits of staying on it. I was too afraid to quit and stayed on it until 36 weeks. Had blood work done monthly and felt good about my little black-and-blue insurance policies. My rainbow baby is 17 days old today and my belly still has some faint bruises visible.<br><br>
Please keep us posted!<br><br>
Amy
 

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Slogirl -<br><br>
I am also a redhead and I bruise very easily. I also have very low BP (might be a red head thing), mine is 98/60 usually. I am cold all of the time, but I was told it was due to the hormones of pregnancy last time -LOL!<br><br>
I know the injections can be a pain but they are so worth it for the end result. Good luck!!!!<br><br>
Take care,<br><br>
Jen
 

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Discussion Starter · #11 ·
Thanks to all who responded!<br><br>
Background:<br>
Original recommendation for 16 weeks came from Endocrinologist. He turned me back over to my OB for ongoing care after 10 weeks.<br><br>
Update:<br>
At our 12 week US with the regular OB, I mentioned that I felt a little uncertain about going off after 16 weeks, and was curious as to why he thought it might be beneficial. His response? "I share your concern. As long as it continues to not pose any problems I would like to keep you on it through 28 weeks."<br><br>
Ahhh, sigh of relief.
 

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I'm on Lovenox as well 1x/day after having 4 m/c's. Hoping this will be the magic cure. My midwife, OB, and RE have all been talking to each other and consulting which makes me feel much more at ease.<br>
Here's to shooting up for the babe!
 
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