I was super depressed during my first trimester. My midwife suggested that I wait until the 2nd trimester, and then I could take zoloft. My depression lifted somewhat at that point, so I decided to hold off. In short, (from what i recall) I read that zoloft (and others) appear safe and have not demonstrated to cause any problems; but I guess nothing is guaranteed 100%, so one should weigh whether the individual feels the depression warrants the meds. I don't know if that was so helpful, but I was sort of procrastinating trying anti dep medications, was going to try them finally, and then got pg, so now I'm procrastinating again...