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Discussion Starter #1
I just got results sent to me, and I cannot afford to see the doctor right now as I am paying out of pocket. All of my blood tests have been really expensive. I just got results from Igenex and do now know how to interpret them.<br><br>
test:<br>
IFA, B BURGDOREFRI < 1:40 TITER<br>
NEGATIVE<br><br>
LYME IgG wetern blot:<br><br>
Igenex-IGG Result: Negative<br>
CDC/NYS RESULT: Negative<br><b><br>
31kda was INDETERMINATE<br>
and<br>
41Kda : ++</b><br><br>
everything else, negative.<br><br>
LYME IgM western blot:<br>
igenex:negative<br>
cdc:negative<br><br><b>41kda ... +++</b><br>
everything else: -<br><br>
I think this is saying my results are negative but im not completely sure. thank you!
 

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I tested through IGeneX too. My overall dx was negative, but like you, I had some positive bands & indeterminates. Band 41 had 3 pluses in my results but all that means is that I have a lot of something swimming around with a flagella (tail.) The head of IGeneX in Palo Alto told me that an Inuit who spent their entire life on an iceburg would test positive for band 41, everyone has stuff swimming around. I also had a single positive for bands 58 & 66 and an "inderterminate" on bands 39 & 83/93. 66 worries me the most since I only know of two bacteria with heat shock proteins - Lyme & Syphilis (& I know I don't have the latter.) Fwiw, I treated for 8 weeks & never noticed a difference in my symptoms.<br><br>
Did you get the Lyme vax? Band 31 is Lyme indicative - see below:<br><br><div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">Disease surveillance is close observation of a group of patients with the same disease, and it is one of the jobs of the Centers for Disease Control (CDC). Criteria used for disease surveillance is often different than criteria used to diagnose and treat patients. In my opinion, surveillance criteria should not be used in day-to-day clinical medical practice. Unfortunately, many patients are told they do not have borreliosis because they do not meet CDC’s surveillance criteria. Surveillance criteria exclude some of the classic hallmark antibodies, such as the 31 kDa band (outer surface protein A or ospA) and the 34 kDa band (outer surface protein B or ospB). <b>In fact, the 31 kDa band is so tightly associated with Lyme borreliosis that a vaccine was made from that outer surface protein. In other words, I believe that criteria that exclude the ospA (31 kDa) band should not be used to tell a patient they do not have Lyme borreliosis.</b> Common sense should tell anyone that prevalent antibodies like the 31 dKa and 34 dKa should be included in the criteria, not excluded. <b>(Remember, research supports that if just one antibody that is significantly associated with Borrelia burgdorferi is present on a Western blot, 97 percent of those patients with chronic symptoms or chronic diseases feel better with antibiotics.)</b></td>
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The author of the above is "Dr C of Missouri." (Lyme docs often stay under the radar for fear of their licenses being revoked for not complying with the government.)<br><br>
Here's an explanation of all of the bands:<br><br><div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">18: An outer surface protein.<br><br>
22: Possibly a variant of outer surface protein C.<br><br>
23-25: Outer surface protein C (osp C).<br><br>
28: An outer surface protein.<br><br>
30: Possibly a variant of outer surface protein A.<br><br>
31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).<br><br>
37: Unknown, but it is in the medical literature that it is a borrelia-associated antibody. Other labs consider it significant.<br><br>
39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.<br><br>
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.<br><br>
45: Heat shock protein. This helps the bacteria survive fever. The only bacteria in the world that does not have heat shock proteins is Treponema pallidum, the cause of syphilis.<br><br>
58: Heat shock protein.<br><br>
66: Heat shock protein. This is the second most common borrelia antibody.<br><br>
73: Heat shock protein.<br><br>
83: This is the DNA or genetic material of Borrelia burgdorferi. It is the same thing as the 93, based upon the medical literature. But laboratories vary in assigning significance to the 83 versus the 93.<br><br>
93: The DNA or genetic material of Borrelia burgdorferi.<br><br>
In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.<br><br>
These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93. This is true regardless of whether it is IgG or IgM.. But again, there is no universal agreement on the significance of these bands. <b>Betina Wilska, M.D</b>. from Germany is one of the world's experts on outer surface protein A (31 kDa).</td>
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Discussion Starter #3
<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Metasequoia</strong> <a href="/community/forum/post/14541583"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">I tested through IGeneX too. My overall dx was negative, but like you, I had some positive bands & indeterminates. Band 41 had 3 pluses in my results but all that means is that I have a lot of something swimming around with a flagella (tail.) The head of IGeneX in Palo Alto told me that an Inuit who spent their entire life on an iceburg would test positive for band 41, everyone has stuff swimming around. I also had a single positive for bands 58 & 66 and an "inderterminate" on bands 39 & 83/93. 66 worries me the most since I only know of two bacteria with heat shock proteins - Lyme & Syphilis (& I know I don't have the latter.) Fwiw, I treated for 8 weeks & never noticed a difference in my symptoms.<br><br>
Did you get the Lyme vax? Band 31 is Lyme indicative - see below:<br><br><br><br>
The author of the above is "Dr C of Missouri." (Lyme docs often stay under the radar for fear of their licenses being revoked for not complying with the government.)<br><br>
Here's an explanation of all of the bands:</div>
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Wow, thank you. To my knowledge I have never had a Lyme vax, I dont think.<br>
So do you think I should test again? Or maybe just set up an appt with my doc and see what he thinks...hmmm....
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>nataliachick7</strong> <a href="/community/forum/post/14542523"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">Wow, thank you. To my knowledge I have never had a Lyme vax, I dont think.<br>
So do you think I should test again? Or maybe just set up an appt with my doc and see what he thinks...hmmm....</div>
</td>
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Yea, I figured you'd be too young to have had the Lyme vax - thank goodness.<br><br>
What are your symptoms?
 

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Discussion Starter #5
my symptoms are<br><br>
constantly fatigued/ exhausted (to the point that i cannot function like a normal person)<br>
low blood pressure<br>
low blood sugar<br>
dizzy and passing out<br>
irritable<br>
moody<br>
headaches<br>
heavy periods<br>
weight gain<br>
constant sugar cravings<br><br>
theres probably more that im missing but thats most of it.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">constantly fatigued/ exhausted (to the point that i cannot function like a normal person)<br>
low blood pressure<br>
low blood sugar<br>
dizzy and passing out</td>
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I've had these same symptoms to varying degrees for the past 3.5 years. I finally found a brilliant ND who diagnosed me with fairly severe adrenal fatigue. The dizziness & passing out can be attributed to the low blood pressure. In fact, a standard test for adrenal fatigue is to lie down on your back & relax for about 5 minutes. Have someone take your BP while laying down. Then stand up & have someone take your BO immediately upon standing. And then take it again 30 seconds later. Ideally, your BP should rise when you stand & stay the same 30 seconds later. If it doesn't rise upon standing or even drops upon standing - you can figure out how severe your adrenal fatigue is.<br>
This is the first thing my ND does when I see him. We chat for a few minutes just so I relax a bit (& don't skew my BP results because of the hustle & bustle of getting there.) I can always tell how good or bad my BP will be by how dizzy I feel when I stand up.<br>
My BP is *always* low which is a sure sign of adrenal fatigue.<br><br>
The adrenal glands regulate our hormones - our sex hormones & our stress hormones - including insulin. If our adrenals aren't functioning properly, blood sugar issues are likely. I can also tell when my adrenals have taken a hit because I react more strongly to sugar/carbs. When I've been taking care of myself, I can have a small bowl of ice cream & not notice any change - but if I've overdone it, I immediately feel dizzy & get heart palps.<br><br>
My fatigue hasn't been the type where I want to lay in bed & sleep all day, but more a lack of motivation - more of a mental fatigue. I *definitely* have a fierce brain fog - which improves when I take adrenal supplements.<br><br><div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">irritable<br>
moody<br>
headaches<br>
heavy periods<br>
weight gain<br>
constant sugar cravings</td>
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These can all be attributed to hormonal imbalances including sex hormones & cortisol, a stress hormone - all can be caused by adrenal dysfunction.<br><br>
When I was first diagnosed with adrenal fatigue, I wasn't reacting to gluten (it's part of the ASI, adrenal stress index test.) The following two years, I reacted to gluten & I completely removed it from my diet. I didn't have my cycles when I was first tested because Ds was just under a yr old & almost exclusively nursing. When I got my cycles back in May of 2008, for teh first time in my life, they were normal! They used to be unpredictable, heavy, painful, horrible PMS & bloating, weepiness, acne, you name it. I've had my cycles back for 1.5 years now & they come every 31 days, ZERO PMS, no bloating, no acne, no mood swings, only 5 days long & very light bleeding. I don't know if it was because I started healing my adrenals or if it was the gluten, but I suspect the latter because I still have days where I know that my adrenals aren't functioning so well. A year ago I went through a really stressful time when I almost lost my father & my adrenals tanked - yet my cycles remained regular & symptom free - but I was gluten free.<br><br>
Weight gain is associated with high cortisol levels. I don't know when my levels were high (adrenal fatigue begins with high cortisol levels from constant stress & as it goes on, untreated, your cortisol becomes depleted - which I where I was when I was diagnosed, barely any cortisol left.) Typically, the belly is the area where fat accumulates when high cortisol is the cause.<br><br>
My ND always says that the thyroid is almost always affected when the adrenals aren't functioning properly - even if it doesn't show up on blood tests. You can't heal the thyroid before addressing the adrenals - trying to do so can actually make things worse because you're making the adrenals work harder.<br><br>
So, why would you have adrenal fatigue? It could be life's stresses, or it could be some underlying condition like Lyme. Either way, your body can't heal from Lyme unless you heal your adrenals. For this reason, I decided to focus all of my energy on healing my adrenals. My main symptom was probably anxiety & that was the first thing to disappear. It had been nearly crippling, my whole adult life. It took about 9 months of healing before I suddenly noticed one day that it was GONE!<br><br>
My physical complaints are chronic muscle pain & floaters (spots in my vision) which came on rather suddenly 3 years ago. My ND insists that both of these can be attributed to adrenal fatigue (even though they're very common Lyme symptoms.)<br>
When I think about it, nothing has ever been cyclical with me the way it is with Lyme. With Lyme, you have flare ups - usually monthly because the Lyme bacteria has a 28 day life cycle. I've never had flare ups. My muscle pain never comes & goes, it's constant. If anything, it's gotten a bit better over the past 3 years. I've never had joint pain or fevers either & it seems unlikely that in 3 years, I wouldn't have experienced either at some point.<br><br>
HTH
 

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Discussion Starter #7
Thank you so much. This is just mind boggling to me, you see, I had an adrenal saliva test and everything was NORMAL as was my cortisol. very strange. My thyroid tests (free t4 free t3 and so on) were normal. TSH was 2.98-slightly elevated but to most docs normal.<br>
I started myself on nutri meds porcine thyroid and am not really seeing any results.<br>
I just dont know what to think. <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/greensad.gif" style="border:0px solid;" title="greensad"><br>
I also have high cholestrol, forgot to mention that.
 

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What's your cholesterol like? It's quite controversial & some believe that high cholesterol is not a negative thing.<br><br>
I'm amazed that your ASI was normal! I've always wondered if anyone would ever have a normal result. Who interpreted the results for you?
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Metasequoia</strong> <a href="/community/forum/post/14555871"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">What's your cholesterol like? It's quite controversial & some believe that high cholesterol is not a negative thing.<br><br>
I'm amazed that your ASI was normal! I've always wondered if anyone would ever have a normal result. Who interpreted the results for you?</div>
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My total cholestrol is 269<br><br>
LDL is 170<br>
My blood tests show I have a "Higher relative cardiovascular risk according to CDC guidelines". Scary, Im only 24!<br><br>
And i had Genova diagnostics do my adrenal test.<br>
I know, its mind boggling.<br><br>
Thanks <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/smile.gif" style="border:0px solid;" title="smile">
 
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