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Discussion Starter · #1 ·
I would really appreciate it.<br><br>
I'm interested in what it says about Clonazepam (Klonapin). It's a psychiatric medication, in the benzodiazepam family.<br><br>
Thank you.
 

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what i've found is that it is unknown if it is expressed in milk...<br><br>
it is, however, dangerous to take during pregnancy because of known harm to the fetus.<br><br>
"PREGNANCY: Clonazepam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Clonazepam is best avoided in the first trimester, and probably throughout pregnancy.<br><br>
NURSING MOTHERS: It is not known if clonazepam is secreted in breast milk."<br><br><a href="http://www.medicinenet.com/clonazepam/article.htm" target="_blank">http://www.medicinenet.com/clonazepam/article.htm</a><br><br><a href="http://drugsafetysite.com/clonazepam" target="_blank">http://drugsafetysite.com/clonazepam</a>
 

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Discussion Starter · #3 ·
Yeah, I haven't taken it during my pregnancy because of the risk of fetal abnormalities.<br><br>
I was hoping that Hale might have something to say about it, as conventional wisdom is that he is more thorough/knowledgable than other med sources.<br><br>
So, can anyone tell me what it says in his book? <img alt="" class="inlineimg" src="/img/vbsmilies/smilies/loveeyes.gif" style="border:0px solid;" title="Loveeyes">:
 

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From his website, it looks like it is okay, but to watch for sedation in the baby.<br><br>
Here's one post about it.<br><br><a href="http://66.230.33.248/discus/messages/43/47757.html" target="_blank">http://66.230.33.248/discus/messages/43/47757.html</a>
 

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<div style="margin:20px;margin-top:5px;">
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<div>Originally Posted by <strong>YumaDoula</strong> <a href="/community/forum/post/8985755"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">Yeah, I haven't taken it during my pregnancy because of the risk of fetal abnormalities.<br><br>
I was hoping that Hale might have something to say about it, as conventional wisdom is that he is more thorough/knowledgable than other med sources.<br><br>
So, can anyone tell me what it says in his book? <img alt="" class="inlineimg" src="/img/vbsmilies/smilies/loveeyes.gif" style="border:0px solid;" title="Loveeyes">:</div>
</td>
</tr></table></div>
Clonazepam is a typical benzo diazepam sedative, anticonvulsant. In one case report, milk levels varied between 11 and 13 ug/L (the maternal doswas omitted). Milk/serum ratio was approximately .33. In this report, the infant's serum level of clonazepam dropped from 4.4 ug/L at birth to 1/0 ug/L at 14 days while continuing to breastfeed.<br><br>
Pregnancy Risk Category: C<br>
Lactation Risk Category: L3<br>
Theoretic Infant Dose: 2.0 ug/kg/dady<br>
Adult Concerns: Apnea, sedation, ataxia, hypotonia. Behavorial disturbances (in children) include aggressiveness, irratability, agitation.<br>
Pediatric Concerns: None reported via milk. Observe for sedation.<br>
Drug interaction: Phenytoin and barbiturates may increase clearance of clonazepam. CNS depressants may increase sedation<br><br>
Alternatives: (none listed)<br><br>
Adult Dosage: .5-1 mg TID<br><br>
T1/2=18-50 hours<br>
PHL= (blank)<br>
PK= 1-4 hours<br>
MW= 316<br>
Vd=1.5-4.4<br>
M/P= .33<br>
PB= 50-86%<br>
Oral=complete<br>
pKa= 1.5, 10.5
 

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<a href="http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" target="_blank">http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT</a><br><br>
For your future reference--this is a website where you can look up drugs. Run by NIH.
 

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Discussion Starter · #7 ·
Thank you, everyone.<br><br>
Now I just wish the answer was more clear-cut. I'm definitely having a difficult time with my anxiety and panic attacks while not taking it. It affects my relationship with my dh and the kids. But the pregnancy risks are too great. However, if I can take it safely while bfing, I'd really like to.
 
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