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Discussion Starter #1
Okay so got off the phone with the midwife she mentioned two u/s tests one for genetic (two blood tests and one US) around 14 weeks? if I remember correctly and another at 18 (or so weeks forgive my preggo brain) for anotomical (can't spell either) issues.<br><br>
I have religious issues with termination of most pregnancies so I do see a benefit in being prepared but wanted to know what your thoughts on testing were? Can they see downs from an anotomical c/s?
 

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I'm not positive, but she may be referring to the Triple Screen test? I'm seriously considering not doing this one this time around - it has an incredibly high amount of false positives due to dates being off and they will not retest. My feelings for this was b/c with my 2nd son, from the results, they said there was a 1 in 10 chance of Down's and then they were trying to push for an amnio and all sorts of unnecessary things IMO. I did have a level 2 u/s as my DH has a heart condition that could be genetic so they needed to do the fetal echo and all. During the Level 2 they found none of the markers for Down's. I believe that they can only look for markers on the u/s, shape of nose, facial features and so forth.
 

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The first test she mentioned is a Nuchal Fold Translucency u/s combined with an intergrated serum blood test (2 part blood test, one draw at X week and the other a few weeks later.) Those three things combined give about a 90% accuracy in detecting a genetic disorder. It is the most accurate, non-invasive genetic screening, but it is not diagnostic. Meaning, if it puts you at a higher risk, you would have to get an amnio to know 100%. If you are unlikely to terminate, personally I don't see much point in such extensive and expensive testing. The NF u/s can only been done by specialized u/s techs, most likely at a Maternal Fetal experts office. If you are "low risk", the intergated serum blood test is probably a good enough screening, though less accurate.<br><br>
Yes, the 18-20 wk u/s can sometimes detect genetic complications, but not always. Not all babies with Down syndrome have visible markers via u/s. There are several things they will measure and look for, but again, no guarentees.<br><br>
I have one son with Down syndrome. I did not take any genetic testing in my pg with him and nothing abnormal was detected via u/s. In fact, he wasn't even dx until he aspirated and stopped breathing when he was 3 wks old and we were life-flighted to a children's hospital.<br><br>
I am 36, will be 37 at the birth. I am not planning on having the NF test or amnio. I'm on the fence about the intergrated serum test. I don't feel it is terribly reliable, but I am curious about the results nonetheless.<br><br>
I have done a lot of research into genetic testing, so feel free to ask me any questions & I will try to help.
 

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Discussion Starter #4
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<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">it has an incredibly high amount of false positives due to dates being off</td>
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Since I am not sure of what my LMP is there is a likelyhood it would be off anyhow. I'd like to be prepared for any medical issues (heart defects) so I am on the fence...
 

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Just adding, the Triple Screen or Quad screen tests are one time blood draws and less reliable than the intergrated serum test. What makes the 2 part test more reliable is that they measure your levels at each test and compare the growth of certain factors. Lemmie find a link... here you go, this explains the process very well: <a href="http://www.health.uab.edu/13781/" target="_blank">http://www.health.uab.edu/13781/</a> The blood test can be done without the NF u/s.
 

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She is probably referring to the nuccal translucency test (the early one). That is a detailed u/s where the technician looks for markers (specifically the bridge of the nose and the neck, or nuccal (sp?) folds) and also bloodwork. It is not 100% accurate and is only a screen but it gives you odds for various trisomies. It is non-invasive.<br><br>
As for the level II u/s, I don't know that it really screens for chromosomal issues other than that it can catch certain markers.<br><br>
Anyway, whether to have testing is a very personal choice and I think you should follow your heart. Many people who do test do so not because they would terminate an "imperfect" pregnancy but because they want to know ahead of time. I do so because I am a worrier and I would want to prepare for life with a child with special needs -- research schools, educate myself, prepare my family, etc.
 

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Discussion Starter #7
how accurate are those tests for multiple pregnancies?<br>
Just curious (will find out if its one, two <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/wink1.gif" style="border:0px solid;" title="wink1"> on Tuesday)
 

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They won't doo the blood tests alone with multiples, it is completly inaccurate if there is more than one. You can do NF u/s on multiples, provided the tech can get a clear view of what they need to measure. HTH
 

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<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">I do so because I am a worrier and I would want to prepare for life with a child with special needs -- research schools, educate myself, prepare my family, etc.</td>
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My thoughts exactly.<br><br>
I will be 38 in August. I am getting the nuchal translucency test (in the next few weeks), the Quad Screen, and the Level II ultrasound.<br><br>
Last time (twin pg) I did the quad screen and the level II.
 

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I have a history of down syndrome in my family. My brother has it, and it really turned my parents' lives upside down when the found out (after he was born). During my last 2 pregnancies, I had the nuchal fold u/s combined with the blood tests. They came back normal. Then, at my doctor's urge, I had the triple screen/quad screen done. It came back with a very high chance that my second child (my daughter) would have down syndrome. I did not have the amnio because it's so risky. She was born fine, and is completely perfect.<br><br>
I will not have the triple screen/quad screen done again. It caused all sorts of unnecessary worry, and didn't give us any answers. . . just more concerns. I understand wanting to know if the baby has spina bifida (which is the other thing the quad screen tests for) but it's not worth the worry to me.
 

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My doc's office offers the quad screen and the nuchal translucency tests. I did the quad with my DS because that was all they offered. I'm thinking of doing the nuchal translucency test this time around but I'm not sure. It would be nice to see baby on the ultrasound again due to all my worrying.
 

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<div>Originally Posted by <strong>peacelovingmama</strong> <a href="/community/forum/post/10311724"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">Anyway, whether to have testing is a very personal choice and I think you should follow your heart. Many people who do test do so not because they would terminate an "imperfect" pregnancy but because they want to know ahead of time. I do so because I am a worrier and I would want to prepare for life with a child with special needs -- research schools, educate myself, prepare my family, etc.</div>
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That is a good reson to get screened, but unfortunately the majority of people do not test for that reason. <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/65500197/ABSTRACT?CRETRY=1&SRETRY=0" target="_blank">Termination rates & prenatal diagnois</a> Over 90% of babies diagnoised with Down syndrome are terminated. I belive this is largely due to parents recieving unbalanced information and excessive urging to terminate from their careproviders rather than seeking to educate themselves first.<br><br>
I do wish for heathy babies for everyone on this DDC, but know that sometimes unepected news can be a wonderful blessing.
 

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With my first baby, I used an OB practice that was Christian and they informed newly pg mothers that they would not perform these kind of tests and if we wanted them, we would have to go to another practice to get them. The only screening they did was the u/s at 20 weeks to detect anatomical problems. It was fine with me. I knew I wouldn't terminate and there's really nothing I could do during pregnancy if my baby did have a problem. I also knew that sometimes the tests could give false positives and what pg mommy really needs that added worry/stress during pregnancy. Not knowing would be much better for me emotionally than knowing and not being able to do a darn thing about it. I think it would interfer greatly with my ability to bond with the baby and enjoy being pg if I was given bad news like that. I would be sick with worry and that wouldn't be good for me or the baby. This time around, I'm with a different care provider and will decline the tests if they are offered. I will do the 20 week u/s but that's all.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>MySunflowerBoys</strong> <a href="/community/forum/post/10312493"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">That is a good reson to get screened, but unfortunately the majority of people do not test for that reason. <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/65500197/ABSTRACT?CRETRY=1&SRETRY=0" target="_blank">Termination rates & prenatal diagnois</a> Over 90% of babies diagnoised with Down syndrome are terminated. I belive this is largely due to parents recieving unbalanced information and excessive urging to terminate from their careproviders rather than seeking to educate themselves first.<br><br>
I do wish for heathy babies for everyone on this DDC, but know that sometimes unepected news can be a wonderful blessing.</div>
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I know you are right about those statistics and about unbalanced information. In fact, when I had my amnio last time, the genetic counselor talked a lot in terms of "ending" the pregnancy if they detected a "problem" or "issue." I had to keep telling her that we weren't planning a termination. It was/is sad.<br><br>
Anyway, I wish healthy babies for everyone too and I'm sure you are right about unexpected news ending up being a wonderful blessing. Your boys are beautiful (I checked out your slideshow)!
 

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We won't be doing any fetal testing. I would never terminate a pregnancy and I have seen what false positives can do to families. There is no family history to suggest that there might be a problem and I would never do any of the more invasize test if they found something on and initial screenings so I would just spend the rest of the pregnancy a nervous wreck. Not worth it for us.
 

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<img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/offtopic.gif" style="border:0px solid;" title="offtopic">:<br>
My mom was part of the testing that help develop the blood test when she was pregnant with my little brother.
 

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I don't do those types of testing because they can have a high rate of false positives.<br>
I wouldn't choose to terminate.<br>
The tests can be dangerous and cause miscarriage.<br><br>
So I just don't do them. Its really a personal choice but you should look at the risks and benefits. Find out what the tests will give you. What the chances are of anything actually being wrong. Get all the information you can and then make your own decision.
 

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<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Pyrodjm</strong> <a href="/community/forum/post/10313935"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">We won't be doing any fetal testing. I would never terminate a pregnancy and I have seen what false positives can do to families. There is no family history to suggest that there might be a problem and I would never do any of the more invasize test if they found something on and initial screenings so I would just spend the rest of the pregnancy a nervous wreck. Not worth it for us.</div>
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<img alt="" class="inlineimg" src="/img/vbsmilies/smilies/yeahthat.gif" style="border:0px solid;" title="yeah that">:<br><br>
I might do a non-invasive test if I had risk factors, but I'd just do more reading on how to take care of a child with whatever tested as positive.
 

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I know that the triple screen and quad screen blood tests have high rates of false positives, but my understanding is that most of these are due to incorrect dating of the pregnancy. If you know exactly when you conceived, what does that do to your chances of a false positive? My pregnancy happened via donor insemination, so there is absolutely no question about the date.<br><br>
I'm considering doing the blood test, basically in hopes that it will be negative and put my mind at ease. Probably wouldn't do an amnio even with a positive, if the false positive rate is very high, but I'm wondering how accurate it is if you're sure of your dates...
 

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Discussion Starter #20
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<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">I used an OB practice that was Christian and they informed newly pg mothers that they would not perform these kind of tests and if we wanted them, we would have to go to another practice to get them.</td>
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I think its good they are upfront and state what their view point is from the get go it probably makes a lot of mothers think.<br><br>
I may do the tests but I'd ignore the results...so maybe there's no point.<br><br>
I had my parent teacher interview today for my 3yr olds preschool and was told - no big surprise to me - he's cognatively delayed born a month early oxygen deprived at birth...(but socially and emmotionally above average).<br><br>
I realise that I cannot emmotionally put myself in a position where I'd even have those thoughts if things came back wonky and if they came back 100% okay it still doesn't mean you couldn't get surprise at birth. I think I'll just do the anatomical as if it was a ds child they do often have heart issues(?) and stuff that would need to be prepared for ahead of time..<br><br>
but not to the point that people might question hey if you knew you could have....yeah don't need that. They are born we love them when they are incapable of anything and that's enough for me.<br><br>
Okay I think I am going to cry (hormones)
 
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