chel - I definitely have mixed feelings about starting meds! DH & I have only been trying for one year (had a chemical pregnancy in Feb), but we're both almost 37 so we went and had a fertility w/u 3 months ago. It didn't really show anything - slightly low motility for DH, and nothing abnormal for me. I've been charting for 15 months, have very regular cycles, always O, and have 2-3 days of good EWCM - so why no baby?!?
My fear is that I'm too anxious - I've been taking antidepressants for mild-moderate anxiety/depression for several years. When we started TTC I switched to zoloft which is the most prego-friendly, but doesn't work quite as well for me - plus there's the worry/stress of unsuccessful TTC while every couple weeks another friend tells me she's pg! My RE suggested meds right away, but I didn't want to take them for fear they'd make my anxiety worse (you always hear about the women who got pg AFTER they "quit trying"!). But, 3 more months of seeing AF changed my mind. So here I am on day 2 of clomid, definitely anxious (I've already cried over the IDEA of freaking out on DH or my dear sister for no reason!) but also excited because maybe this is going to do it.
For me, I don't think of it as a sign that we're not meant to have children - I've tried to look at it as a chance to realize how important it is to both of us to have them. I hope that will carry over into an appreciation of our dc and maybe a little more patience when we do have them.
Thanks for starting this thread - I'd love to talk more about this and hear from others who got over their cold feet!